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dc.contributor.authorTan, Jintong-
dc.contributor.authorWang, Yiwen-
dc.contributor.authorGong, Xiaohui-
dc.contributor.authorLi, Jing-
dc.contributor.authorZhong, Wenhua-
dc.contributor.authorShan, Liqin-
dc.contributor.authorLei, Xiaoping-
dc.contributor.authorZhang, Qian-
dc.date.accessioned2024-12-18T04:33:30Z-
dc.date.available2024-12-18T04:33:30Z-
dc.date.issued2022-06-01-
dc.identifier.issn1684-1182-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/9233-
dc.description.abstractAbstract Background: To investigate antibiotic resistance of pathogens responsible for neonatal invasive bacterial infections (IBIs) in China. Methods: Cross-sectional study of neonates with IBI evaluated in nine hospitals in China (January 2012eAugust 2019). Antibiotic resistance patterns of pathogens responsible for neonatal IBIs were analyzed. Results: Of 3770 full-term neonates who were subjected to lumbar puncture and a blood culture, IBIs were diagnosed in 460 neonates (12.2%). Escherichia coli and Group B Streptococcus (GBS) were the leading pathogens, followed by Enterococcus spp, and Staphylococcus aureus. E. coli expressed high resistance to ampicillin (72.0%) and third-generation cephalosporins (cefotaxime, 34.8%; ceftriaxone, 38.1%). The prevalence of extended spectrum beta-lactamase (ESBL)-producing E. coli was 34.1%. The proportions of E. spp resistant to penicillin and ampicillin were 60% and 54.1%. All S. aureus showed resistance to ampicillin and penicillin. Theresistance rate of S. aureus to methicillin was 50%. Although all GBS were susceptible to penicillin and ampicillin, the proportions of GBS resistant to erythromycin and clindamycin were 75.9% and 77.3%. Antibiotic susceptibility appeared to improve in 2019. Susceptibility of E. coli to ampicillin, cefotaxime, and ceftriaxone improved to 42.9%, 76.9%, and 71.4% in 2019, compared with 12.5%, 37.5%, and 50% in 2012. The prevalence of ESBL-producing E. coli declined to 20% in 2019, lower than 100% in 2012. Susceptibility of GBS to erythromycin and clindamycin improved from 0% in 2012 to 28.6% and 25% in 2019. Conclusions: The prevalence of antibiotic resistance is high in neonates in China, although there is a favorable declining trend in recent years.en_US
dc.language.isoenen_US
dc.publisherElsevier Taiwan LLCen_US
dc.subjectAntibiotic resistance;en_US
dc.subjectChina;en_US
dc.subjectInvasive bacterial infections(IBIs);en_US
dc.subjectNeonateen_US
dc.titleAntibiotic resistance in neonates in China 2012e2019: A multicenter studyen_US
dc.typeArticleen_US
Appears in Collections:VOL 55 NO 3 2022

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