Please use this identifier to cite or link to this item:
http://localhost:8080/xmlui/handle/123456789/9227
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Petrillo, Sara | - |
dc.contributor.author | Giovanna Gallo, , Maria | - |
dc.contributor.author | Santoro, Annapaola | - |
dc.contributor.author | Brugaletta, Rita | - |
dc.contributor.author | Nijhawan, Parni | - |
dc.contributor.author | Russo, Cristina | - |
dc.date.accessioned | 2024-12-18T04:13:00Z | - |
dc.date.available | 2024-12-18T04:13:00Z | - |
dc.date.issued | 2022-06-01 | - |
dc.identifier.issn | 1684-1182 | - |
dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/9227 | - |
dc.description.abstract | Abstract Background/purpose: The non-protein thiol glutathione is protective against infection by Mycobacterium tuberculosis (MTB) and, together with the transcription factor NRF2 (the nuclear factor erythroid 2-related factor 2), plays a crucial role in counteracting MTBinduced redox imbalance. Many genes implicated in the antioxidant response belong to the NRF2-signalling pathway, whose central role in the pathogenesis of tuberculosis (TB) has been recently proposed. Methods: In this study, we measured GSH levels in blood of patients with active TB and analysed the individual NRF2-mediated redox profile, in order to provide additional tools for discriminating the pathologic TB state and addressing therapeutic interventions.Results: Our findings show a systemic individual modulation of GSH and NRF2 signaling pathway in patients with TB, with a "personalized" induction of NRF2-target genes. Conclusion: This study can provide useful tools to monitor the course of the infection and address patients’ treatment | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Taiwan LLC | en_US |
dc.subject | NRF2; | en_US |
dc.subject | Glutathione; | en_US |
dc.subject | Oxidative stress; | en_US |
dc.subject | Redox profile; | en_US |
dc.subject | Tuberculosis (TB) patients | en_US |
dc.title | Personalized profiles of antioxidant signaling pathway in patients with tuberculosis | en_US |
dc.type | Article | en_US |
Appears in Collections: | VOL 55 NO 3 2022 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
405-412.pdf | 555.29 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.