Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/9190
Title: High baseline frequencies of natural killer cells are associated with asymptomatic SARS-CoV-2 infection
Authors: K. Graydon, Elizabeth
M.W. Malloy, Allison
Machmach, Kawthar
Keywords: NK cells Natural killer cells SARS-CoV-2 Asymptomatic Symptomatic
Issue Date: 2023
Abstract: This study tested the hypothesis that high frequencies of natural killer (NK) cells are protective against symptomatic SARS-CoV-2 infection. Samples were utilized from the COVID-19 Health Action Response for Marines study, a prospective, observational study of SARS-CoV-2 infection in which participants were enrolled prior to infection and then serially monitored for development of symptomatic or asymptomatic infection. Frequencies and phenotypes of NK cells (CD3􀀀 CD14􀀀 CD19􀀀 CD56+) were assessed by flow cytometry. Individuals that developed asymptomatic infections were found to have higher pre-infection frequencies of total NK cells compared to symptomatic individuals (10.61% [SD 4.5] vs 8.33% [SD 4.6], p = 0.011). Circulating total NK cells decreased over the course of infection, reaching a nadir at 4 weeks, while immature NK cells increased, a finding confirmed by multidimensional reduction analysis. These results indicate that NK cells likely play a key role in controlling the severity of clinical illness in individuals infected with SARS-CoV-2.
URI: http://localhost:8080/xmlui/handle/123456789/9190
Appears in Collections:VOL 4 2023

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