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dc.contributor.authorTumwine-Downey, Irene-
dc.contributor.authorDeroost, Katrien-
dc.contributor.authorLevy, Prisca-
dc.contributor.authorMcLaughlin, Sarah-
dc.contributor.authorHosking, Caroline-
dc.contributor.authorLanghorne, Jean-
dc.date.accessioned2024-12-18T02:05:48Z-
dc.date.available2024-12-18T02:05:48Z-
dc.date.issued2023-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/9188-
dc.description.abstractAdvances in transcriptomics and proteomics have revealed that different life-cycle stages of the malaria parasite, Plasmodium, share antigens, thus allowing for the possibility of eliciting immunity to a parasite life-cycle stage that has not been experienced before. Using the Plasmodium chabaudi (AS strain) model of malaria in mice, we investigated how isolated exposure to blood-stage infection, bypassing a liver-stage infection, yields significant protection to sporozoite challenge resulting in lower liver parasite burdens. Antibodies are the main immune driver of this protection. Antibodies induced by blood-stage infection recognise proteins on the surface of sporozoites and can impair sporozoite gliding motility in vitro, suggesting a possible function in vivo. Furthermore, mice lacking B cells and/or secreted antibodies are not protected against a sporozoite challenge in mice that had a previous blood-stage infection. Conversely, effector CD4+ and CD8+ T cells do not seem to play a role in protection from sporozoite challenge of mice previously exposed only to the blood stages of P. chabaudi. The protective response against preerythrocytic stages can be induced by infections initiated by serially passaged blood-stage parasites as well as recently mosquito transmitted parasites and is effective against a different strain of P. chabaudi (CB strain), but not against another rodent malaria species, P. yoelii. The possibility to induce protective cross-stage antibodies advocates the need to consider both stage-specific and cross-stage immune responses to malaria, as natural infection elicits exposure to all life-cycle stages. Future investigation into these cross-stage antibodies allows the opportunity for candidate antigens to contribute to malaria vaccine developmenten_US
dc.titleAntibody-dependent immune responses elicited by blood stage-malaria infection contribute to protective immunity to the pre-erythrocytic stagesen_US
dc.typeArticleen_US
Appears in Collections:VOL 4 2023

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