Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/9168
Full metadata record
DC FieldValueLanguage
dc.contributor.authorChen, Yi-Syong-
dc.contributor.authorTu, Yueh-Hua-
dc.contributor.authorChen, Bo-Han-
dc.contributor.authorLiu, Yen-Yi-
dc.contributor.authorHong, Yu-Ping-
dc.contributor.authorTeng, , Ru-Hsiou-
dc.contributor.authorWang, You-Wun-
dc.contributor.authorChiou, Chien-Shun-
dc.date.accessioned2024-12-17T03:51:43Z-
dc.date.available2024-12-17T03:51:43Z-
dc.date.issued2022-02-01-
dc.identifier.issn1684-1182-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/9168-
dc.description.abstractAbstract Background: Cholera, a rapidly dehydrating diarrheal disease caused by toxigenic Vibrio cholerae, is a leading cause of morbidity and mortality in some regions of the world. Core genome multilocus sequence typing (cgMLST) is a promising approach in generating genetic fingerprints from whole-genome sequencing (WGS) data for strain comparison among laboratories. Methods: We constructed a V. cholerae core gene allele database using an in-house developed computational pipeline, a database with cgMLST profiles converted from genomic sequences from the National Center for Biotechnology Information, and built a REST-based web accessible via the Internet. Results: We built a web service platformdcgMLST@Taiwan and installed a V. cholerae allele database, a cgMLST profile database, and computational tools for generating V. cholerae cgMLST profiles (based on 3,017 core genes), performing rapid global strain tracking, and clustering analysis of cgMLST profiles. This web-based platform provides services to researchers, public health microbiologists, and physicians who use WGS data for the investigation of cholera outbreaks and tracking of V. cholerae strain transmission across countries and geographic regions.en_US
dc.language.isoenen_US
dc.publisherElsevier Taiwan LLCen_US
dc.subjectVibrio cholerae;en_US
dc.subjectMolecular typing;en_US
dc.subjectWhole-genome sequencing;en_US
dc.subjectWeb service;en_US
dc.subjectCore genome multilocus sequence typing (cgMLST);en_US
dc.subjectStrain trackingen_US
dc.titlecgMLST@Taiwan: A web service platform for Vibrio cholerae cgMLST profiling and global strain trackingen_US
dc.typeArticleen_US
Appears in Collections:VOL 55 NO 1 2022

Files in This Item:
File Description SizeFormat 
102-106.pdf530.67 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.