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DC Field | Value | Language |
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dc.contributor.author | Shintani, Arisa | - |
dc.contributor.author | Fukai, Shoko | - |
dc.contributor.author | Nobusawa, Reika | - |
dc.date.accessioned | 2024-12-17T03:14:28Z | - |
dc.date.available | 2024-12-17T03:14:28Z | - |
dc.date.issued | 2022 | - |
dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/9154 | - |
dc.description.abstract | Lymphocytes regulate the immune response by circulating between the vascular and lymphatic systems. High endothelial venules, HEVs, special blood vessels expressing selective adhesion molecules, such as PNAd and MAdCAM-1, mediate naïve lymphocyte migration from the vasculature into the lymph nodes and Peyer’s patches. We have identified that DACH1 is abundantly expressed in developing HEV-type endothelial cells. DACH1 showed a restricted expression pattern in lymph node blood vessels during the late fetal and early neonatal periods, corresponding to HEV development. The proportion of MAdCAM-1+ and CD34+ endothelial cells is reduced in the lymph nodes of neonatal conventional and vascular-specific Dach1-deficient mice. Dach1- deficient lymph nodes in adult mice demonstrated a lower proportion of PNAd+ cells and lower recruitment of intravenously administered lymphocytes from GFP transgenic mice. These findings suggest that DACH1 promotes the expression of HEV-selective adhesion molecules and mediates lymphocyte trafficking across HEVs into lymph nodes. | en_US |
dc.subject | Lymphocyte Lymph node Endothelial cell Transcription factor Trafficking | en_US |
dc.title | Dach1 transcription factor regulates the expression of peripheral node addressin and lymphocyte trafficking in lymph nodes | en_US |
dc.type | Article | en_US |
Appears in Collections: | VOL 3 2022 |
Files in This Item:
File | Description | Size | Format | |
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175-185.pdf | 13.41 MB | Adobe PDF | View/Open |
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