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DC Field | Value | Language |
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dc.contributor.author | Kim, Hangeun | - |
dc.contributor.author | -Eun Kim, Hyeoung | - |
dc.contributor.author | Chung, Dae Kyun | - |
dc.contributor.author | Ok Jang, Kyoung | - |
dc.date.accessioned | 2024-12-17T03:04:07Z | - |
dc.date.available | 2024-12-17T03:04:07Z | - |
dc.date.issued | 2022-02-01 | - |
dc.identifier.issn | 1684-1182 | - |
dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/9149 | - |
dc.description.abstract | Abstract Lipoteichoic acid isolated from Staphylococcus aureus (aLTA) is known to regulate the production of pro-inflammatory cytokines through TLR2-mediated signaling pathways. In our previous study, we found that aLTA significantly increased manganese superoxide dismutase (MnSOD) in the THP-1 human monocyte-like cell line, but the role of MnSOD in the regulation of cytokine production was not elucidated. In the current study, we found that MnSOD was involved in aLTA-mediated cytokine production. The signaling pathways associated with aLTAmediated MnSOD induction in THP-1 cells included TLR2-MyD88-IRAK2, JNK (c-Jun N-terminal kinases)1/2 and nuclear factor- kB (NF-kB). We also found MnSOD was involved in the regulation of IL-1b and TNF-a, which were induced by early signaling pathways, including JNK1/2, p38, and NF-kB p65. In addition, MnSOD was also involved in the production of IL-6 and CCL2 in aLTA-stimulated THP-1 cells through activation of late signaling pathways such as JAK2-STAT3. Taken together, our data suggest that aLTA-mediated MnSOD production involved in the regulation of cytokine production and it may be the cause of one of the excessive inflammatory reactions caused by S. aureus. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Taiwan LLC | en_US |
dc.subject | Staphylococcus aureus; | en_US |
dc.subject | Lipoteichoic acid; | en_US |
dc.subject | Manganese superoxide dismutase; | en_US |
dc.subject | Cytokine; | en_US |
dc.subject | Inflammation | en_US |
dc.title | Manganese superoxide dismutase induced by lipoteichoic acid isolated from Staphylococcus aureus regulates cytokine production in THP-1 cells | en_US |
dc.type | Article | en_US |
Appears in Collections: | VOL 55 NO 1 2022 |
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