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dc.contributor.authorGrifoni, Alba-
dc.contributor.authorSette, Alessandro-
dc.date.accessioned2024-12-17T02:58:34Z-
dc.date.available2024-12-17T02:58:34Z-
dc.date.issued2022-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/9143-
dc.description.abstractIt is critically important to understand how the adaptive immune response, elicited by vaccination or infection, recognizes SARS-CoV-2. This is especially true when considering the challenges to the immune response posed by variant evolution. Herein, we summarize our work aimed at characterizing the magnitude of the CD4+ and CD8+ T cell responses to SARS-CoV-2, the proteins most frequently recognized, and the associated T cell epitope repertoire. This work formed the foundation for our most recent studies aimed at understanding and predicting the ability of T cell responses induced by SARS-CoV-2 infection or vaccination to subsequently cross-recognize novel SARS-CoV-2 variants. We found that T cell responses are remarkably preserved and able to crossrecognize SARS-CoV-2 variants, from Alpha to Omicron. This is distinct from what has been observed for the SARS-CoV-2- specific antibody and B cell responses. This body of work, supported by independent studies carried out by other groups, suggests that T cells may contribute to a second line of defense against infection while also limiting viral spread and, thus, disease severityen_US
dc.subjectSARS-CoV-2 Variants of concern CD4 CD8en_US
dc.titleFrom Alpha to omicron: The response of T cellsen_US
dc.typeArticleen_US
Appears in Collections:VOL 3 2022

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