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dc.contributor.authorDwi Daningrat, Wa Ode-
dc.contributor.authorAmalia, Hafsah-
dc.contributor.authorMarti Ayu, Ira-
dc.contributor.authorSatzke, Catherine-
dc.contributor.authorSafari, Dodi-
dc.date.accessioned2024-12-17T02:54:56Z-
dc.date.available2024-12-17T02:54:56Z-
dc.date.issued2022-02-01-
dc.identifier.issn1684-1182-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/9139-
dc.description.abstractAbstract A number of pneumococcal carriage studies in children have been conducted in recent years. However, summary data of carriage prevalence and serotype distribution from South East Asia Region (SEAR) are limited. This may lead to the misconception that Streptococcus pneumoniae vaccine-types are uncommon in the region. Systematic reviews of pneumococcal carriage and the distribution of serotypes are critically important for evidence-based decision-making. We aimed to summarize published data on the serotype prevalence of S. pneumoniae carried in the nasopharynx of children under 5 years of age in SEAR. We performed a systematic review and meta-analysis for relevant studies on S. pneumoniae carriage conducted prior to PCV program implementation from online journal databases published between January 2001 to December 2019. The pooled prevalence of S. pneumoniae in healthy children under 5 years of age in SEAR was 36.0% (95% CI 34.2%e37.8%), and ranged from 68.0% (95% CI: 61.9%e74.0%) in Cambodia to 7.6% (95% CI: 5.7%e9.6%) in Malaysia. Serotypes 6A/B, 23F and 19F were the most common serotypes in children <5 years, accounting for 12.9% (95% CI: 9.4%e16.3%), 9.3% (95% CI: 5.9%e12.8%) and 10.1% (95% CI: 6.6%e13.5%) of isolates, respectively. Vaccine policy makers should take these results into account when making decisions on pneumococcal conjugate vaccine programs implementation. Given the paucity of dataen_US
dc.language.isoenen_US
dc.publisherElsevier Taiwan LLCen_US
dc.subjectStreptococcus pneumoniae carriage;en_US
dc.subjectPneumococcal conjugate vaccine;en_US
dc.subjectSoutheast Asiaen_US
dc.titleCarriage of Streptococcus pneumoniae in children under five years of age prior to pneumococcal vaccine introduction in Southeast Asia: A systematic review and meta-analysis (2001e2019)en_US
dc.typeArticleen_US
Appears in Collections:VOL 55 NO 1 2022

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