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DC Field | Value | Language |
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dc.contributor.author | Hiroshi Tanimoto | - |
dc.contributor.author | Shigemura, Katsumi | - |
dc.contributor.author | Osawa, Kayo | - |
dc.contributor.author | Kado, Mitsuki | - |
dc.contributor.author | Onishi, Reo | - |
dc.contributor.author | Fang, Shiuh-Bin | - |
dc.date.accessioned | 2024-12-16T07:46:55Z | - |
dc.date.available | 2024-12-16T07:46:55Z | - |
dc.date.issued | 2023-02 | - |
dc.identifier.citation | Original Article | en_US |
dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/9112 | - |
dc.description.abstract | Abstract Background: Hypermucoviscous (HMV) Klebsiella pneumoniae produces large amounts of capsular polysaccharides, leading to high mortality. Since extended spectrum beta-lactamase (ESBL)-producing HMV K. pneumoniae strains have increased in Japan, we investigated and compared the antimicrobial susceptibilities and genetic characteristics of Methods: We investigated 291 ESBL-producing K. pneumoniae collected between 2012 and 2018, and in them 54 HMV strains were identified and comparable 53 non-HMV strains were selected. Then, ESBL gene detection, plasmid replicon typing, and virulence gene detection were done by PCR amplification. Results: Almost all of the HMV K. pneumoniae strains possessed uge (98.1%), wabG (96.3%), rmpA (94.4%), iucA (79.6%), fimH (70.4%), iroB (70.4%), and peg-344 (70.4%). These genes were found less frequently in non-HMV strains (uge 20.8%, wabG 83.0%, rmpA 7.5%, iucA 3.8%, fimH 9.4%, iroB 5.7%, and peg-344 1.9%). K2 capsule type (40.7%) was most common in HMV strains. HMV strains showed higher resistance to cefepime (p Z 0.001) and piperacillin/tazobactam (p Z 0.005) than non-HMV strains. CTX-M-15 (75.9%, 60.4%) was the dominant ESBL type in both HMV and non-HMV strains, and the most common plasmid replicon type was IncFII (52.1%) in CTX-M-15-producing strains. Conclusions: We found that HMV strains had more virulence genes and showed higher resistance to antibiotics than non-HMV strains. The most common capsule type was K2. CTX-M-15 was the most common type of ESBL gene in both HMV and non-HMV strains in Japan. The FII plasmid might be related to the spread of CTX-M-15 among K. pneumoniae strains. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Journal of Microbiology, Immunology and Infection | en_US |
dc.subject | Hypermucoviscous (HMV) Klebsiella pneumoniae | en_US |
dc.subject | Hypervirulence in K. pneumoniae (hvKp) | en_US |
dc.subject | Extended spectrum beta-lactamase (ESBL) | en_US |
dc.subject | CTX-M-15 | en_US |
dc.subject | Plasmid | en_US |
dc.title | Comparative genetic analysis of the antimicrobial susceptibilities and virulence of hypermucoviscous and nonhypermucoviscous ESBL-producing Klebsiella pneumoniae in Japan | en_US |
dc.type | Article | en_US |
Appears in Collections: | VOL 56 NO 1 2023 |
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File | Description | Size | Format | |
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93-103.pdf | 477.06 kB | Adobe PDF | View/Open |
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