Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/9105
Title: End-of-treatment HBsAg, HBcrAg and HBV RNA predict the risk of off-treatment ALT flares in chronic hepatitis B patients
Authors: Brakenhoff, Sylvia M.
Knegt, Robert J. de
Campenhout, Margo J.H. van
Eijk, Annemiek A. van der
Brouwer, Willem P.
Bo¨mmel, Florian van
Keywords: Hepatitis B virus
Serum biomarkers
Liver
HBV
Hepatology
Flare
Issue Date: Feb-2023
Publisher: Journal of Microbiology, Immunology and Infection
Citation: Original Article
Abstract: Abstract Background/Purpose(s): Since ALT flares after therapy withdrawal are associated with adverse outcomes, risk stratification is of major importance. We aimed to study whether off-treatment flares are related with virological outcomes, and if serum levels of novel biomarkers at end-of-treatment (EOT) can predict flares. Methods: Chronic hepatitis B patients who participated in three global randomised trials of peginterferon-based therapy were studied (99e01, PARC, ARES). HBV RNA, HBsAg and HBcrAg were quantified at EOT. Associations between EOT biomarker levels and flares were assessed as continuous data and after categorisation. Flares were defined as ALT 5xULN during six months after therapy cessation. Results: We included 344 patients; 230 HBeAg-positive and 114 HBeAg-negative. Patients were predominantly Caucasian (77.0%) and had genotype A/B/C/D in 23.3/7.3/13.4/52.3%. Flares were observed in 122 patients (35.5%). Flares were associated with lower rates of sustained response (3.5% vs 26.8% among patients with and without a flare; p < 0.001). Higher HBsAg (OR 1.586, 95%CI 1.231e2.043), HBV RNA (OR 1.695, 95%CI 1.371e2.094) and HBcrAg (OR 1.518, 95%CI 1.324e1.740) levels were associated with higher risk of flares (p < 0.001). Combinations of biomarkers further improved risk stratification, especially HBsAg þ HBV RNA. Findings were consistent in multivariate analysis adjusted for potential predictors including HBeAgstatus and EOT-response (HBV DNA <200 IU/mL). Conclusion: Off-treatment ALT flares were not associated with favourable virological outcomes. Higher EOT serum HBsAg, HBcrAg and HBV RNA were associated with a higher risk of flares after therapy withdrawal. These findings can be used to guide decision-making regarding therapy discontinuation and off-treatment follow-up.
URI: http://localhost:8080/xmlui/handle/123456789/9105
Appears in Collections:VOL 56 NO 1 2023

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