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DC Field | Value | Language |
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dc.contributor.author | Chien, Ying-Chun | - |
dc.contributor.author | Chang, Chin-Hao | - |
dc.contributor.author | Huang, Chun-Kai | - |
dc.contributor.author | dkk. | - |
dc.date.accessioned | 2024-12-14T06:46:18Z | - |
dc.date.available | 2024-12-14T06:46:18Z | - |
dc.date.issued | 2024-04 | - |
dc.identifier.issn | 1684-1182 | - |
dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/9055 | - |
dc.description.abstract | Background: This study investigates the impact of nontuberculous mycobacterial lung disease (NTM-LD) on mortality and mechanical ventilation use in critically ill patients. Methods: We enrolled patients with NTM-LD or tuberculosis (TB) in intensive care units (ICU) and analysed their association with 30-day mortality and with mechanical ventilator-free survival (VFS) at 30 days after ICU admission. Results: A total of 5996 ICU-admitted patients were included, of which 541 (9.0 %) had TB and 173 (2.9 %) had NTM-LD. The overall 30-day mortality was 22.2 %. The patients with NTM-LD had an adjusted hazard ratio (aHR) of 1.49 (95 % CI, 1.06-2.05), and TB patients had an aHR of 2.33 (95 % CI, 1.68-3.24), compared to ICU patients with negative sputum mycobacterial culture by multivariable Cox proportional hazard (PH) regression. The aHR of age<65 years, obesity, idiopathic pulmonary fibrosis, end-stage kidney disease, active cancer and autoimmune disease and diagnosis of respiratory failure were also significantly positively associated with ICU 30-day mortality. In multivariable Cox PH regression for VFS at 30 days in patients requiring invasive mechanical ventilation, NTM-LD was negatively associated with VFS (aHR 0.71, 95 % CI: 0.56e0.92, p Z 0.009), while TB showed no significant association. The diagnosis of respiratory failure itself predicted unfavourable outcome for 30-day mortality and a negative impact on VFS at 30 days. Conclusions: NTM-LD and TB were not uncommon in ICU and both were correlated with increasing 30-day mortality in ICU patients. NTM-LD was associated with a poorer outcome in terms of VFS at 30 days. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Journal of Microbiology, Immunology and Infection | en_US |
dc.relation.ispartofseries | Original Article;328-336 | - |
dc.subject | NTM-LD | en_US |
dc.subject | Tuberculosis | en_US |
dc.subject | ICU mortality | en_US |
dc.subject | Ventilator-free survival | en_US |
dc.title | The impact of nontuberculous mycobacterial lung disease in critically ill patients: Significance for survival and ventilator use | en_US |
dc.type | Article | en_US |
Appears in Collections: | Vol. 57 No. 2 (2024) |
Files in This Item:
File | Description | Size | Format | |
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328-336.pdf | 648.31 kB | Adobe PDF | View/Open |
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