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DC Field | Value | Language |
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dc.contributor.author | Budi Hartop, Anggoro | - |
dc.contributor.author | Wulan Anggrahini, Dyah | - |
dc.contributor.author | G. Satwiko, Muhammad | - |
dc.date.accessioned | 2024-12-14T06:43:27Z | - |
dc.date.available | 2024-12-14T06:43:27Z | - |
dc.date.issued | 2022 | - |
dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/9049 | - |
dc.description.abstract | Background: Atrial septal defect developed pulmonary hypertension (ASD-PH) at first diagnosis due to late presentation are common in Indonesia. Transthoracic echocardiogram (TTE) is a common tool to detect ASD-PH, before proceeding to invasive procedure. The NT-proBNP measurement to screen ASD-PH is not yet considered the standard approach, especially in limited resource conditions. The objective of this study is to assess the value of NT-proBNP, along with simple TTE parameter, to screen PH among adults with ASD. Methods: This was a cross-sectional study. The subjects were adult ASD-PH patients from the COHARDPH registry (n=357). Right heart catheterization (RHC) was performed to diagnose PH. Blood sample was withdrawn during RHC for NT-proBNP measurement. The TTE was performed as standard procedure and its regular parameters were assessed, along with NT-proBNP, to detect PH. Results: Two parameters significantly predicted PH, namely NT-proBNP and right atrial (RA) diameter. The cut-off of NT-proBNP to detect PH was ≥140 pg/mL. The cut-off of RA diameter to detect PH was ≥46.0 mm. The combined values of NT-proBNP level ≥140 pg/mL and RA diameter ≥46.0 mm yielded 46.6% sensitivity, 91.8% specificity, 54.3% accuracy, 96.5% positive predictive value and 26.2% negative predictive value to detect PH, which were better than single value. Conclusion: NT-proBNP level ≥140 pg/mL represented PH in adult ASD patients. The NT-proBNP level ≥140 pg/mL and RA diameter ≥46.0 mm had a pre-test probability measures to triage patients needing more invasive procedure and also to determine when and if to start the PH-specific treatment. Keywords: atrial septal defect, N-terminal pro-BNP, pulmonary arterial hypertension, diagnostic test | en_US |
dc.subject | atrial septal defect, N-terminal pro-BNP, pulmonary arterial hypertension, diagnostic test | en_US |
dc.title | Usefulness of Combining NT-proBNP Level and Right Atrial Diameter for Simple and Early Noninvasive Detection of Pulmonary Hypertension Among Adult Patients with Atrial Septal Defect | en_US |
dc.type | Article | en_US |
Appears in Collections: | VOL 54 NO 4 2022 |
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5.crdownload | 621.85 kB | Unknown | View/Open |
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