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dc.contributor.authorLin, Chia-ling-
dc.contributor.authorLee, Kuo-Huang-
dc.contributor.authorHuang, Wan-Ting-
dc.contributor.authordkk.-
dc.date.accessioned2024-12-14T04:57:29Z-
dc.date.available2024-12-14T04:57:29Z-
dc.date.issued2024-02-
dc.identifier.issn1684-1182-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/9019-
dc.description.abstractBackground: Children with allergic rhinitis (AR) have substantially more acute rhinosinusitis than children without AR. We evaluated whether intranasal corticosteroids (INCS), second-generation antihistamines (SGH), and/or intranasal antihistamines (INH) for AR affect acute rhinosinusitis in children with AR aged 2e18 years. Methods: By using the National Health Research Institutes Database 2005 of Taiwan, a cohort of patients with AR aged 2e18 years treated with AR medications between 2002 and 2018 was made, within which a nested caseecontrol study was performed. Risk settings for acute rhinosinusitis cases matched controls for age, sex, and comorbidities. Current users of INCS, INH, and/or SGH were compared with remote and recent users of any AR medications and current users of INCS with and without SGH were compared with current users of SGH. Results: Current users of SGH and/or INCS had a higher risk of acute rhinosinusitis than remote users of AR drugs, and current users of SGH had a higher risk of acute rhinosinusitis than recent users; however, no difference in the risk of acute rhinosinusitis was found between current users of INCS and recent users of AR drugs. Current users of INCS with and without SGH had a lower risk of acute rhinosinusitis than current users of SGH alone. Conclusions: Treatment of INCS with and without SGH diminished the risk of acute rhinosinusitis compared with treatment using SGH alone. Adequate INCS treatment for patients with AR is important to reduce the incidence of acute rhinosinusitis.en_US
dc.language.isoen_USen_US
dc.publisherJournal of Microbiology, Immunology and Infectionen_US
dc.relation.ispartofseriesOriginal Article;175-183-
dc.subjectAllergic rhinitisen_US
dc.subjectAcute rhinosinusitisen_US
dc.subjectIntranasal corticosteroiden_US
dc.subjectSecond-generation antihistaminesen_US
dc.subjectNested caseecontrol studyen_US
dc.titleIntranasal corticosteroids reduced acute rhinosinusitis in children with allergic rhinitis: A nested caseecontrol studyen_US
dc.typeArticleen_US
Appears in Collections:Vol. 57 No. 1 (2024)

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