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DC Field | Value | Language |
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dc.contributor.author | Suh, Jin Woong | - |
dc.contributor.author | Park, Seung Min | - |
dc.contributor.author | Ju, Yong Kuk | - |
dc.contributor.author | dkk. | - |
dc.date.accessioned | 2024-12-14T04:50:23Z | - |
dc.date.available | 2024-12-14T04:50:23Z | - |
dc.date.issued | 2024-02 | - |
dc.identifier.issn | 1684-1182 | - |
dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/9013 | - |
dc.description.abstract | Background/Purpose: To investigate the virulence profiles and identify clinical and microbiological predictors of mortality in patients with carbapenem-resistant Acinetobacter baumannii (A. baumannii) bacteremia. Methods: This retrospective cohort study enrolled adult patients with carbapenem-resistant A. baumannii (CRAB). Multivariate logistic regression was used to identify the predictors of 30-day mortality. All isolates were subjected to real-time polymerase chain reaction for virulence factors and genotyped using multilocus sequence typing. Results: Among the 153 patients with CRAB bacteremia, 66 % received appropriate definitive antibiotic therapy. The in-hospital and 30-day mortality rates were 58.3 and 23.5 %, respectively. Ultimately, we enrolled 125 patients with CRAB bacteremia in the analysis, excluding early mortality cases. All CRAB isolates carried blaOXA-23 and blaOXA-51. The clinical strains belonged to 10 sequence types (STs), and the major genotypes were ST191, ST195, ST451, and ST784. The distribution of virulence factors included surface adhesion (Ata, 84.8 %; ChoP, 7.2 %), biofilm formation (OmpA, 76.8 %), killing of host cells (AbeD, 99.2 %), toxins (LipA, 99.2 %), and conjugation (BfmR, 90.4 %). In multivariate logistic regression analysis, hemodialysis due to acute kidney injury and moderate to severe thrombocytopenia were significant risk factors associated with 30-day mortality. However, microbiological factors were not significant predictors. Conclusions: Clinical factors such as hemodialysis due to acute renal injury and moderate to severe thrombocytopenia have a greater influence on mortality in CRAB bacteremia compared with microbiological factors. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Journal of Microbiology, Immunology and Infection | en_US |
dc.relation.ispartofseries | Original Article;148-155 | - |
dc.subject | Acinetobacter baumannii | en_US |
dc.subject | Bacteremia | en_US |
dc.subject | Carbapenemresistant | en_US |
dc.subject | Mortality | en_US |
dc.subject | Risk factors | en_US |
dc.title | Clinical and molecular predictors of mortality in patients with carbapenemresistant Acinetobacter baumannii bacteremia: A retrospective cohort study | en_US |
dc.type | Article | en_US |
Appears in Collections: | Vol. 57 No. 1 (2024) |
Files in This Item:
File | Description | Size | Format | |
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148-155.pdf | 311.15 kB | Adobe PDF | View/Open |
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