Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/9013
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSuh, Jin Woong-
dc.contributor.authorPark, Seung Min-
dc.contributor.authorJu, Yong Kuk-
dc.contributor.authordkk.-
dc.date.accessioned2024-12-14T04:50:23Z-
dc.date.available2024-12-14T04:50:23Z-
dc.date.issued2024-02-
dc.identifier.issn1684-1182-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/9013-
dc.description.abstractBackground/Purpose: To investigate the virulence profiles and identify clinical and microbiological predictors of mortality in patients with carbapenem-resistant Acinetobacter baumannii (A. baumannii) bacteremia. Methods: This retrospective cohort study enrolled adult patients with carbapenem-resistant A. baumannii (CRAB). Multivariate logistic regression was used to identify the predictors of 30-day mortality. All isolates were subjected to real-time polymerase chain reaction for virulence factors and genotyped using multilocus sequence typing. Results: Among the 153 patients with CRAB bacteremia, 66 % received appropriate definitive antibiotic therapy. The in-hospital and 30-day mortality rates were 58.3 and 23.5 %, respectively. Ultimately, we enrolled 125 patients with CRAB bacteremia in the analysis, excluding early mortality cases. All CRAB isolates carried blaOXA-23 and blaOXA-51. The clinical strains belonged to 10 sequence types (STs), and the major genotypes were ST191, ST195, ST451, and ST784. The distribution of virulence factors included surface adhesion (Ata, 84.8 %; ChoP, 7.2 %), biofilm formation (OmpA, 76.8 %), killing of host cells (AbeD, 99.2 %), toxins (LipA, 99.2 %), and conjugation (BfmR, 90.4 %). In multivariate logistic regression analysis, hemodialysis due to acute kidney injury and moderate to severe thrombocytopenia were significant risk factors associated with 30-day mortality. However, microbiological factors were not significant predictors. Conclusions: Clinical factors such as hemodialysis due to acute renal injury and moderate to severe thrombocytopenia have a greater influence on mortality in CRAB bacteremia compared with microbiological factors.en_US
dc.language.isoen_USen_US
dc.publisherJournal of Microbiology, Immunology and Infectionen_US
dc.relation.ispartofseriesOriginal Article;148-155-
dc.subjectAcinetobacter baumanniien_US
dc.subjectBacteremiaen_US
dc.subjectCarbapenemresistanten_US
dc.subjectMortalityen_US
dc.subjectRisk factorsen_US
dc.titleClinical and molecular predictors of mortality in patients with carbapenemresistant Acinetobacter baumannii bacteremia: A retrospective cohort studyen_US
dc.typeArticleen_US
Appears in Collections:Vol. 57 No. 1 (2024)

Files in This Item:
File Description SizeFormat 
148-155.pdf311.15 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.