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dc.contributor.authorSiwendro, Afrisya Bimo-
dc.contributor.authorRamdan, Ahmad-
dc.contributor.authorIsmiarto, Yoyos Dias-
dc.contributor.authorYantisetiasti, Anglita-
dc.contributor.authorFachri, Dliyauddin-
dc.date.accessioned2024-12-09T07:03:15Z-
dc.date.available2024-12-09T07:03:15Z-
dc.date.issued2024-09-
dc.identifier.citationResearch Articleen_US
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/8812-
dc.description.abstractOsteoporosis is a condition of decreased bone mass density. Pharmacological management uses drugs that decrease bone resorption or increase bone formation. The most commonly used drugs are bisphosphonates. Risedronate is one of these bisphosphonates. It inhibits osteoclasts, resulting in osteoclast apoptosis. Denosumab is a human monoclonal antibody that inhibits receptor activator kappa-B ligand, inhibiting osteoclast activation. Both drugs are widely used. Research on the efficacy of these two mechanisms has yet to obtain conclusive results. β-cross-laps is a parameter that can be used to evaluate the effectiveness of therapy through monitoring the bone resorption process. This experimental study used female rats >9 weeks old and was conducted at the Pharmacology and Therapeutic Laboratory, Universitas Padjadjaran Bandung, Indonesia, from June to September 2021. This study utilized a simple random sampling to allocate 24 experimental animals into three groups: control, risedronate, and denosumab. β-Crosslaps expression values before ovariectomy, post ovariectomy before receiving medication, and post ovariectomy and receiving medication was recorded and statistically analyzed using the SPSS version 24.0. The analysis of 24 samples revealed a statistically significant decrease in the median value of β-Crosslaps after ovariectomy in the denosumab group (p=0.036) when compared to the control group, whereas the decrease in the risedronate group was not significant (p=0.687). Administration of denosumab in rat models is more effective in reducing bone resorption compared to risedronate.en_US
dc.language.isoen_USen_US
dc.publisherMajalah Kedokteran Bandungen_US
dc.subjectβ-cross-lapsen_US
dc.subjectdenosumaben_US
dc.subjectrisedronateen_US
dc.subjectosteoporosisen_US
dc.titleEffectiveness of Short-Term Use Denosumab and Risedronate Using β-Crosslaps and Histopathology as a Parameter in Osteoporotic Rat Modelen_US
dc.typeArticleen_US
Appears in Collections:VOL 56 NO 3 2024

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