The Anti-Malarial Effect of Thespesia populnea (L.) Soland ex Correa Extract Using Malaria Mice Model Infected with P. berghei

Abstract

Introduction: Malaria is a re-emerging disease that still causes high morbidity and mortality rates. Reports of malaria therapy, encouraging studies to find new therapies based on plants and adjuvant in malaria infection. Thespesia populnea or portia tree leaf extract is a plant that has been shown to have anti-inflammatory, antibacterial and antifungal effects. The aim of this study was to analyze the effect of Thespesia populnea leaf extract as antimalarial levels, and and its effect on hemoglobin levels in BALB/C mice infected with Plasmodium berghei ANKA (PbA). Methods: The study was true experimental laboratories using post-test only group design. Using 27 mice were randomly divided into 3 groups: Group with aquades (G1), Group received Chloroquine (G2), and Group with 200 mg/kg bw of Thespesia populnea (L.) Soland ex Correa extract and Chloroquine (G3). The degree of parasitemia was observed serially from the first day to the fourth day. Observation of the number of leukocytes and hemoglobin on the fourth day after the mice were terminated. Results: The results of statistical analysis showed that the administration of Thespesia populnea leef extract 200 mg/kg bw with chloroquine had the effect of decreasing the degree of parasitemia and increasing hemoglobin significantly than G1 group, but there was no significant difference with G2 group, although descriptively there were differences. Conclusion: Based on the results of this study, it can be concluded that Thespesia populnea or portia tree leaf extract has an anti-malarial effect and can also significantly prevent anemia. Key words: BALB/C, Hemoglobin, Malaria, Parasitemia, Thespesia populnea extract.