Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/8729
Title: Hepatoprotective Potentials of Dates Extract (Phoenix dactylifera) in Acetaminophen-Induced Mice
Authors: Andriyanto, Andriyanto
Putra, Hamdika Yendri
Aurelia, Sharon
Mustika, Aulia Andi
Manalu, Wasmen
Subangkit, Mawar
Tarigan, Elpita
Irarang, Yusa
Keywords: Acetaminophen
dates
hepatoprotection
mice
Issue Date: 2023
Publisher: Majalah Kedokteran Bandung (MKB)
Series/Report no.: Research Article;154-160
Abstract: Dates (Phoenix dactylifera) are considered as a well-known fruit consumed by many people in various countries. This study aimed to examine potential effects of dates as a hepatoprotective agent in mice. This study was conducted at the Iratco Group’s eLRosa Laboratory Research Facility, Indonesia, starting from June 2022 to July 2022. Mice from ddY strain were randomly divided into 5 groups (n=5 per group) of positive and negative control groups, and treatment groups 1, 2, and 3. The negative control group as the normal baseline did not receive acetaminophen and date extract. In treatment groups, 30 μL/30 grBW, 60 μL/30 grBW, and 100 μL/30 grBW extract was given per oral to Treatment Group 1, Group 2, and Group 3, respectively for 20 days. On day 21, all treatment groups were induced with 300mg/kgBW acetaminophen for 3 days via the intraperitoneal route. Blood tests were performed on day 24 to measure the serum transaminase level as the parameter of liver damage. The lowest level of transaminase serum was found in group 3 with the highest volume of dates extract, which was 100 μL, followed by group 2 (60 μL), and group 1 (30 μL). There was a significant difference between the positive control group and treatment groups with no significant difference was seen between negative and the treatment groups. This study concludes that dates extract has the potential of being a hepatoprotective agent.
URI: http://localhost:8080/xmlui/handle/123456789/8729
ISSN: 2338-6223
Appears in Collections:VOL 55 NO 3 (2023)

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