Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/8710
Title: Nutmeg Extract Alters Mitochondrial Genes Regulation of Skeletal Muscle Fibers in Aging Rats
Authors: Setiawan, Setiawan
Pratiwi, Yuni Susanti
Lesmana, Ronny
Sari, Galuga Sinalusur
Ramdan, Ahmad
Hartono, Aldo
Fathurachman, Fathurachman
Supratman, Unang
Keywords: Aging
mitchondria
nutmeg
sarcopenia
Issue Date: 2022
Publisher: Majalah Kedokteran Bandung (MKB)
Series/Report no.: Research Article;242-248
Abstract: Nutmeg as one of Indonesia native plants has already been used widely in herbal treatment. It has been demonstrated that nutmeg presents activities related to mitochondria functions. Nutmeg potentially has the effect of peroxisome proliferator activated receptors Υ (PPAR Υ) which contributes to myogenesis, and may alters mitochondrial homeostasis in respiration and biogenesis. In this study, how nutmeg extract alters oxidative process in skeletal muscle of aging rats was explored. Twenty aging Wistar male rats aged 80 weeks old were divided into two groups (control and nutmeg treatment). Nutmeg extract was administered for 12 weeks using a gavage. After that, the soleus muscles were collected, weighted, frozen, and stored at -800C until used. Nutmeg was observed to increase the COX1 (1.9 folds, p<0.01), COX2 (1.6 folds, p<0.05), and COXIV (2.8 folds, p<0.01) gene expressions, in parallel with increased protein carbonyl levels (1.5 folds, p<0,01). Nutmeg treatment also significantly increased the expressions of antioxidant endogen COQ7 (2 folds, p<0,01) and PDSS2 (2 folds, p<0,01) in the soleus muscle. Taken together, nutmeg extract may improve mitochondrial respiratory oxidative activities in type I aging skeletal muscle.
URI: http://localhost:8080/xmlui/handle/123456789/8710
ISSN: 2338-6223
Appears in Collections:VOL 54 NO 4 (2022)

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