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Title: | Ciplukan Fruit Extract (Physalis angulata L.) on IL-12 and Oxidative Stress in Mice Gestational Diabetes Mellitus |
Authors: | Gondo, Harry Kurniawan Haryanti, Elizabeth |
Keywords: | DMG Ciplukan fruit extract IL-12 SOD MDA |
Issue Date: | Sep-2024 |
Publisher: | Pharmacognosy Journal |
Citation: | Research Article |
Abstract: | Gestational diabetes mellitus (GDM) is a common pregnancy complication, characterized by increased blood glucose levels that occur during pregnancy. Oxidative stress in hyperglycemia increases the inflammatory response in GDM by stimulating pro-inflammatory genes. IL-12 is a pro-inflammatory cytokine that is generally involved in inflammatory responses . This research aims to determine the effect of ciplukan fruit extract against IL-12, and Oxidative Stress in Gestational Diabetes Mellitus mice . The method used in this research is RAL (Completely Randomized Design). Analysis of cytokine levels using the ELISA reading method was followed by data analysis using the ANOVA test . The results showed that the treatment given gradually increased the highest cytokine levels in the P4 group showing the highest increase with IL-12 levels of 0.246 pg/mL, SOD of 0.160 U/mg protein, and MDA of 0.070 µmol/L. In this study it can be concluded that the P4 group showed the strongest effect in all parameters, indicating the potential of the agent or intervention as an immunomodulator and antioxidant, although it requires good management of oxidative stress. |
URI: | http://localhost:8080/xmlui/handle/123456789/8647 |
Appears in Collections: | VOL 16 NO 5 2024 |
Files in This Item:
File | Description | Size | Format | |
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1121-1123.pdf | 137.12 kB | Adobe PDF | View/Open |
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