Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/8634
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dc.contributor.authorWardhani, Sofia-
dc.contributor.authorAryati, Aryati-
dc.contributor.authorurwanto, Bambang P-
dc.date.accessioned2024-11-30T03:17:14Z-
dc.date.available2024-11-30T03:17:14Z-
dc.date.issued2024-09-
dc.identifier.citationResearch Articleen_US
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/8634-
dc.description.abstractBackground: The effect of HBO2 alone on Sirt-1 and Syndecan-1 is unknown, even though both molecules are involved in preventing endothelial dysfunction. This study aims to determine the effect of HBO2 on Sirt-1 and Syndecan-1 as therapeutic targets for endothelial dysfunction. Method: This study employed a true experimental post-test design. Twenty male Sprague Dawley rats aged 12-14 weeks were divided into two groups. Diving was carried out in an animal hyperbaric chamber with a dose of 2.4 ATA for 60 minutes. All data were collected 18 hours after diving. Results: Our study revealed that the administration of HBO caused an increase in serum MDA and endothelial NF-kB levels (p = 0.007; p = 0.001, respectively) without an increase in any inflammatory markers, specifically IL-1 and VCAM-1 levels (p = 0.707; p = 0.168, respectively). HBO2 decreased Syndecan-1, a marker of endothelial injury (p = 0.026), but did not affect endothelial eNOS and Sirt-1. Conclusion: HBO2 did not cause endothelial injury and inflammation, but the dose used was not enough to increase Sirt-1 levels. Additional research is needed to determine a hormesis dose that can increase Sirt-1 levels.en_US
dc.language.isoen_USen_US
dc.publisherPharmacognosy Journalen_US
dc.subjectSirt-1en_US
dc.subjectSyndecan-1en_US
dc.subjectHBO2en_US
dc.subjectEndothelial dysfunctionen_US
dc.titleThe Effect of HBOT on SIRT-1 and SYNDECAN-1 as Therapeutic Targets for Endothelial Dysfunctionen_US
dc.typeArticleen_US
Appears in Collections:VOL 16 NO 5 2024

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