Biomarker Profiles Associated with Covid-19 Mortality in East Java, Indonesia: A Tertiary Care Hospital Study

Abstract

Objective: This study aimed to compare the most useful biomarkers for predicting prognosis and response to therapy in COVID-19 patients. Material and Methods: This quantitative study involved 639 patients who were hospitalized with COVID-19 infection. Patients without any biochemical marker result; patients referred to another hospital; and peripheral oxygen levels measured using oxygen supplementation were excluded from the study. Results: There was a statistically significant difference in terms of demographics, vital signs on admission, and laboratory parameters. The risk of mortality in COVID-19 is significantly influenced by c-reactive protein (CRP) and interleukin-6 (IL-6) levels (p-value <0.05). Conclusion: Findings revealed these biomarkers could help the future development of more personalized treatment and diagnostic approaches. Keywords: Biomarker, COVID-19, Outcome.