Serum Trace Element Levels in Type 2 DM Patients and its Correlation with Glycemic Control

Abstract

Background: Type 2 diabetes mellitus, a chronic metabolic disorder, is known to impact serum trace element levels. Objectives: to investigates the association between serum trace elements (Co, Cr, and Cu) and glycemic control in individuals with type 2 diabetes. Material and Methods: A 209 type 2 diabetes patients from Dr. H. Abdul Moeloek Hospital in Bandar Lampung and Hasan Sadikin Hospital in Bandung participated in the study. Patients underwent assessments for serum trace element levels (Co, Cr, and Cu) and glycemic control indicators (FBG and HbA1c). Results: Results indicated significantly lower Co levels in uncontrolled diabetes versus controlled cases (P<0.05). Co, Cr, and Cu levels displayed a significant negative correlation with HbA1c (P<0.05), while Cr and Cu showed a significant negative correlation with FBG (P<0.05). Age did not show significant correlations with serum trace element levels. Conclusion: serum trace element levels (Co, Cr, Cu) are inversely linked to glycemic control in type 2 diabetes individuals. Keywords: type 2 diabetes mellitus, fasting blood glucose, glycemic control, HbA1c, trace element serum.