Alteration of IL-6, BMP-15 and GDF-9 Levels on PCOS Rat Models After Treated with Syzygium Polyanthum (Wight) Walp Leaves Extract

Abstract

Background: Polycystic ovary syndrome (PCOS) is a global health concern for women in reproductive age women. Numerous studies have been reported an association between chronic inflammation and alteration of cytokine in women with PCOS. Syzygium polyanthum (S. polyanthum) contains antioxidants and has antiinflammation activity. Objectives: This study aims to measure the alteration of IL-6, BMP-15, and GDF-9 in rat PCOS model after treated with S. polyanthum leaves extract. Materials and Methods: The female Wistar rats were divided into five groups (n = 5), K0 (normal control), K1 (PCOS group), and three treatment groups which received three different doses of S. polyanthum leaves extract. The treatment group consisted of PCOS rat models with S. polyanthum leaves extract supplementation of 150 mg/KgBW (P1), 300 mg/KgBW (P2), and 450 mg/KgBW (P3). Results: IL-6 expression was highest in K1 (4,690 ± 0.099) and lowest in the P3 treatment, namely (2,370 ± 0.105). The expression of BMP-15 and GDF-9 was lowest at K1 (2.554 ± 0.04; 4.502 ± 0.050) and highest at P3, namely (2.265 ± 0.072; 4.736±0.074). Conclusion: S. polyanthum leaves extract was significantly effective in decreasing IL-6 expressions, as well as a significant increase in BMP-15 and GDF-9 expressions in the PCOS rat model. Keywords: BMP-15, GDF-9, IL-6, Syzygium polyanthum