Triterpenoids from Agathis robusta Aerial Parts and Their Hepatopotective Activity

Abstract

Objective: While Agathis robusta contains important phytochemical constituents and has been linked to a variety of biological activities, there is currently insufficient research on the plant's total phytochemical constituents or pharmacological activity. Materials and Procedures: The aerial part of Agathis robusta was extracted with 70% methanol and was screened for new phytochemical components. The structures of the isolated compounds were elucidated by spectroscopic data interpretation. The hepatoprotective activity of the isolated compounds was investigated. Results: Four known triterpenoids and two new compounds were isolated for the first time from the methanolic extract of the aerial parts of A. robusta. Conclusion: For the first time, new triterpenoidal saponins with high hepatoprotective activity have been isolated from the aerial portion of A. robusta. As a result, it is suggested that more emphasis be placed on this plant's biological behavior. Key words: Agathis robusta, Triterpenoid saponins, Hepatoprotective activity