Anti-Ulcer Activity of Spray-dried Powders Prepared from Aerial Parts Extracts of Ampelopsis cantoniensis

Abstract

Introduction: Ampelopsis cantoniensis is called “Che day” in Vietnam and has been used as a traditional treatment for inflammatory diseases. Methods: Plant material and hydroalcoholic extract were processed and analyzed for their physicochemical characteristics. A method using HPLC was validated to quantify ampelopsin. Hydroalcoholic extract was spray dried and the powder obtained was characterized in terms of its physicochemical parameters and potential for antiulcerogenic activity. Results: The analytical method proved to be selective, linear, accurate, sensitive. A. cantoniensiss pray dried extract (ACP) was obtained using colloidal silicon dioxide as adjuvant and was shown to possess 25.94 % ampelopsisn. It showed significant antiulcer activity in a model of an indomethacin-induced gastric lesion in rats and also produced a gastroprotective effect. Key words: Ampelopsis cantoniensis, Vitaceae, Spray drying, Antiulcer.