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DC Field | Value | Language |
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dc.contributor.author | Utami, Dwi | - |
dc.contributor.author | Wahyudi, Rezza | - |
dc.contributor.author | Widyaningsih, Wahyu | - |
dc.date.accessioned | 2024-11-13T02:44:17Z | - |
dc.date.available | 2024-11-13T02:44:17Z | - |
dc.date.issued | 2023-03 | - |
dc.identifier.issn | 2088 4559 | - |
dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/7927 | - |
dc.description.abstract | The rare sulphated polysaccharides of green algae have been explored of several activities such as antioxidant, anti-inflammation, anti-bacterial, and anti-virus. Ulva lactuca L is one of the majoring algae species in Indonesia that promosing to be explored as natural anti-inflammation in the inflammation disorders treatment. The purpose of this study was to conduct an in-silico test of anti- inflammatory potency of sulphated polysaccharide chemical constituent of green algae (Ulva lactuca L) against the cyclooxygenase-2 enzyme. The methods used were the preparation of a protein structure database cyclooxygenase-2 enzyme (4COX), protein preparation using the Biovia Discovery Studio application, molecular docking simulation of sulphated polysaccharide compounds on proteins using the Autodock 4.0 application and visualization using Ligpot+ v2.2. The results of docking sulphated polysaccharide compounds with the cyclooxygenase-2 enzyme, showed a best binding affinity energy of Gluconic acid ulvan -7.62 kcal/mol similar to the control drug sodium diclofenac (-7.81 kcal/mol), followed by Iduronic acid Ulvan -7.57 kcal/mol, Fucoidan (-6.11 kcal/mol), Alpha Carrageenan (-6.93 kcal/mol), and Lambda Carrageenan (-5.38 kcal/mol). In the conclusion based on the molecular docking result, the sulphated polysaccharide compounds in Ulva lactuca L are potential to be developed as natural antiinflammatory agent by in vitro and in vivo investigation. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Pharmaciana | en_US |
dc.subject | molecular docking | en_US |
dc.subject | sulphated polysaccharide | en_US |
dc.subject | anti-inflammatory | en_US |
dc.subject | Ulva lactuca L | en_US |
dc.subject | 4COX | en_US |
dc.title | The sulphated polysaccharide compounds from green algae (Ulva lactuca L) as a potential natural anti-inflammatory agent based on molecular docking study targeting cyclooxygenase-2 receptor | en_US |
dc.type | Article | en_US |
Appears in Collections: | VOL 13 NO 2 2023 |
Files in This Item:
File | Description | Size | Format | |
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146-156.pdf | 1.09 MB | Adobe PDF | View/Open |
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