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dc.contributor.authorDamaharyuningtyas, Meta-
dc.contributor.authorKintoko-
dc.contributor.authorDarmawan, Endang-
dc.date.accessioned2024-11-12T03:16:21Z-
dc.date.available2024-11-12T03:16:21Z-
dc.date.issued2022-11-
dc.identifier.issn2088 4559-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/7866-
dc.description.abstractDandruff is a scalp disorder caused by a fungus (Malassezia sp.). Water spinach (Ipomoea aquatica) contains phenolic compounds which have antifungal activity. The purpose of this research is to know the active fraction of water spinach (Ipomoea aquatica) herbs that have an antidandruff activity against Malassezia sp. The study used a true experimental design for an antidandruff activity test. Fractionation of water spinach (Ipomoea aquatica) methanol extracts used column chromatography which stationary phase with silica gel 60 powder and mobile phase with chloroform: ethanol: acetyl acetate (8:2:0,1). In vitro anti-dandruff activity based on minimum inhibitory concentration (MIC) and minimum antifungal concentration (MFC) against Malassezia sp. of human dandruff isolate. The average of MIC and MFC among groups fraction of water spinach (Ipomoea aquatica) methanol extracts compared used Friedman test (p≤ 0,05). Fractionation produces 12 fractions, and fraction number 7 of water spinach (Ipomoea aquatica) herbs have the best anti-dandruff activity against Malassezia sp. with MIC 125 µg/mL and MFC 250 µg/mL identified as a phenolic compound. Based on the results, a fraction of phenolic compounds from water spinach (Ipomoea aquatica) herbs have anti-dandruff activity against Malassezia sp.en_US
dc.language.isoen_USen_US
dc.publisherPharmacianaen_US
dc.subjectMalassezia sp.en_US
dc.subjectphenolic compounden_US
dc.subjectwater spinach (Ipomoea aquatica) herbsen_US
dc.subjectantidandruffen_US
dc.titleFractionation of a phenolic compound from water spinach (Ipomoea aquatica) herbs as anti-dandruff against Malassezia sp.en_US
dc.typeArticleen_US
Appears in Collections:VOL 12 NO 3 2022

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