Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/7864
Full metadata record
DC FieldValueLanguage
dc.contributor.authorS, Made Dwi Pradipta Wahyudi-
dc.contributor.authorArimurni, Dewa Ayu-
dc.contributor.authorSafira, Komang Angelita-
dc.contributor.authorColatama, Erika Yuda-
dc.contributor.authorValenrika, Putu Bisma Duta-
dc.date.accessioned2024-11-12T03:12:50Z-
dc.date.available2024-11-12T03:12:50Z-
dc.date.issued2022-11-
dc.identifier.issn2088 4559-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/7864-
dc.description.abstractDecreased blood supply, high blood sugar level, and a possibility of bacterial infection in diabetic wounds pose risk for limb loss and mortality. Therefore, proper wound care is needed to improve the quality of life of diabetic patients. Vitex trifolia L (Legundi) extract is reported to have antibacterial and antioxidant activity that enhances cell proliferation and migration. The antimicrobial and hemostatic properties of chitosan film are viewed as an ideal material for enhancing wound healing. The film should retain its integrity and flexibility while used on the skin, therefore chitosan was combined with PVA and PVP K30 to improve its quality. The objectives of this study were to optimize the concentration of chitosan, PVP K30, and PVA towards the Legundi extract film properties, and to evaluate its wound healing activity on hyperglycemic mice using an incision wound model. In this study, the film’s compositions were optimized using a simplex lattice design, and the effects of its components on their characteristics, such as thickness, weight, folding endurance, swelling rate, and swelling index, were evaluated. BALB/c Mice were divided into three groups (Group I, Group II, Group III) which were treated with normal saline, placebo film, and Legundi film respectively once daily for 8 days. The result suggested that chitosan and PVA were responsible for affecting the film’s thickness, weight, and folding endurance, whilst PVP K30 was the dominant factor in increasing the swelling index and rate of the film. The optimum formula of Legundi extract films consists of 1.15 %(b/v) chitosan, 1.25 %(b/v) PVP K30, and 1.6 %(b/v) PVA. The animal treated with Legundi extract film have higher wound closure compared to the control and placebo group four days after wound incision (p<0.05). Thus, Legundi extract film was a potential dressing to treat a diabetic wound.en_US
dc.language.isoen_USen_US
dc.publisherPharmacianaen_US
dc.subjectVitex trifolia L.en_US
dc.subjecthydrogel filmen_US
dc.subjectchitosanen_US
dc.subjecthyperglycemicen_US
dc.subjectwound healingen_US
dc.titleFormulation optimization and wound healing activity of vitex trifolia L leaf extract loaded chitosan hydrogel film on hyperglycemic ratsen_US
dc.typeArticleen_US
Appears in Collections:VOL 12 NO 3 2022

Files in This Item:
File Description SizeFormat 
346-357.pdf602.84 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.