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dc.contributor.authorSayed Abd Elkarim, Asmaa-
dc.contributor.authorH. Ahmed, Amal-
dc.contributor.authorM. Elgamal, Abdelbaset-
dc.contributor.authorEl Haggar, Radwan-
dc.contributor.authorKhedr, Alaa-
dc.contributor.authorFouad Shalaby, Mohamed-
dc.contributor.authorBayram, Roula-
dc.contributor.authorShabana, Samah-
dc.date.accessioned2024-11-12T02:58:40Z-
dc.date.available2024-11-12T02:58:40Z-
dc.date.issued2021-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/7857-
dc.description.abstractObjective: This work aims to find a new treatment based on the development of safe natural anti-diabetic mixtures. It assesses the hypoglycemic activity of natural mixtures and determines whether there are any negative side effects from the interaction of the herbs and the herbs. Methods: Six natural mixtures were tested for anti-diabetic activity, which was confirmed by a pathological histological examination. We performed a GC-MS analysis on active mixtures 1 and 2, yielding 54 and 38 compounds, respectively. The major compounds were Gingerol, Butan-2-one and 4-(3-hydroxy-2-methoxyphenyl) (97 and 64.02 per cent). Results: Among the six samples, the organic extract of mixture 1 and 2 showed a significant reduction in BGL compared to the standard drug glimepiride at a dose of 10 mg/kg ip and demonstrated a beneficial effect on renal function in alloxan-induced diabetic mice. These results were confirmed by a histopathological study which revealed that both mixture 1 and mixture 2 had decreased morphological and ultrastructural changes in the triggered liver. Docking of cuminaldehyde, Gingerol and α-Copaenin at the active site of human pancreatic enzymes α-amylase and aldol reductase revealed that these compounds had binding affinity at the active site of the enzymes. Conclusion: Our results revealed the anti-diabetic activity of non-polar mixtures consisting of long chain hydrocarbons, oils and non-polar components, thus suggesting that the herbal formulation is safe and effective for the treatment and complication of type 2 diabetes. Key words: Anti-diabetic herbs, Herb-herb interaction, Medicinal plantsen_US
dc.subjectAnti-diabetic herbsen_US
dc.subjectHerb-herb interaction,en_US
dc.subjectMedicinal plantsen_US
dc.titleEvidence Based Evaluation of Pharmacological Activity and Herb-Herb interaction of Organic Extracts of Certain Natural Anti- Diabetic Mixturesen_US
dc.typeArticleen_US
Appears in Collections:VOL 13 NO 6 2021

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