Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/7852
Title: Emerging role of mesenchymal stem cell-derived extracellular vesicles in periodontal regeneration
Authors: Anvari, Yaldasadat
Afrashteh, Ahmad
Pourkaveh, Sajjad
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Keywords: Extracellular vesicles
Mesenchymal stem cellderived extracellular vesicles
Mesenchymal stem cells
Periodontal regeneration
Regenerative medicine
Issue Date: 2024
Publisher: Journal of Taibah University Medical Sciences
Series/Report no.: Review Article;390-402
Abstract: Periodontitis is a prevalent oral ailment that harms both hard and soft tissues of the periodontium, leading to loosening and eventual removal of the teeth. Current clinical treatments have limitations in achieving complete periodontal tissue regeneration. Mesenchymal stem cells (MSCs) have garnered attention due to their unique characteristics and potential as a promising new therapy for periodontitis. Research suggests that the role of MSCs in regenerative medicine primarily occurs through the paracrine pathway, involving the emission of particles encased by lipids called extracellular vesicles (EVs) abundant in bioactive compounds. These EVs play a vital function in controlling the activities of periodontal tissues and immune system cells, and by influencing the immediate surrounding, thus fostering the healing of periodontal damage and renewal of tissues. EVs obtained from MSCs (MSC-EVs), in the form of a cell-free treatment, offer advantages in terms of stability, reduced immune rejection, and ethical considerations, elevating their potential as a hopeful choice for broad clinical applications. This concise overview highlights the mechanisms of MSC-EVs and the possibilities they hold in clinical application for periodontal regeneration.
URI: http://localhost:8080/xmlui/handle/123456789/7852
ISSN: 1658-3612
Appears in Collections:Vol 19 No 2 (2024)

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