Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/7851
Title: In vitro antimicrobial activity and formulation of herbal anti-acne gel containing Rhizophora stylosa fruits extract
Authors: Azrifitria
Purwaningsih, Sri
Fatmala, Annisa Rahma
Keywords: antibacterial
herbal gel
red mangrove fruits
Rhizophora stylosa
Issue Date: Nov-2022
Publisher: Pharmaciana
Abstract: Mangrove fruits have a variety of bioactive metabolites that may control microbial growth. The present study was conducted to formulate and evaluate the antibacterial activities of Rhizophora stylosa fruit extract. The antibacterial activity of R. stylosa crude extract was investigated against Staphylococcus aureus, Staphylococcus epidermidis, and Propionibacterium acnes by disc diffusion method. The herbal gel formulations were developed using different concentrations of kappa carrageenan and Carbomer 940 as the gelling agent. The physicochemical characteristics and in vitro antibacterial activity of the gel were evaluated. The results revealed that the extract had a minimum inhibitory concentration value of 0.05 mg/ml against S. aureus and P. acne, and 0.1 mg/mL against S. epidermidis. All herbal gel formulations with 0.5% w/w of the extract showed a strong inhibitory activity against P. acnes. The herbal gel showed a good homogeneity, pH, viscosity, spreadability, and physical stability in an accelerated condition. Among all formulation studied, F1 was considered as the optimized formulation which contains 0.5% of the R. stylosa fruit extract with 0.25% kappa carrageenan and 0.5% Carbomer 940. It can be concluded that the developed gel formulation has potential against Acne vulgaris. Further research is needed to determine the safety and efficacy so R. stylosa can be developed as an alternative natural anti-acne agent.
URI: http://localhost:8080/xmlui/handle/123456789/7851
ISSN: 2088 4559
Appears in Collections:VOL 12 NO 3 2022

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