Probing the antinociceptive and therapeutic potential of probiotics in managing temporomandibular joint arthritis

Abstract

This literature review explored the antinociceptive and therapeutic effects of probiotic therapy (PT) in the treatment of arthritic conditions affecting the temporomandibular joint (TMJ). Indexed databases were searched without time and language restrictions up to and including February 2023, to identify studies addressing the question: “Is PT effective for the management of TMJ arthritis?” The following keywords were used in different combinations with Boolean operators: arthritis, osteoarthritis, pain, probiotic, rheumatoid, temporomandibular disorders, and temporomandibular joint. Original clinical and experimental studies assessing the therapeutic efficacy of PT in the management of osteoarthritis were eligible for inclusion. Letters to the editor, reviews, commentaries, perspectives, and expert opinions were not sought. The structure of the current review was tailored to encapsulate relevant information. A total of 297 relevant studies were identified during the initial literature search, and the full text and reference lists of these studies were scrutinized. To date, the potential role of PT in managing osteoarthritis of the TMJ region remains uninvestigated. No clinical trials in the indexed literature have assessed the efficacy of PT in managing TMJ arthritis; however, this finding does not preclude a potential role of probiotics as antinociceptive and therapeutic agents in susceptible populations.