Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/7838
Title: Associations among gene polymorphisms, crestal bone loss, and bone mineral density in patients receiving dental implants
Authors: Agrawal, Kaushal Kishor
Singh, Neetu
Chand, Pooran
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Issue Date: 2024
Publisher: Journal of Taibah University Medical Sciences
Series/Report no.: Original Article;313-320
Abstract: Objectives: Interleukin 1 (IL-1) and interleukin 6 (IL-6) gene polymorphisms have been suggested to be responsible for diminished bone mineral density (BMD) and high crestal bone loss (CBL) in some individuals. However, the effects of systemic BMD on variations in periimplant CBL are unclear. Hence, this study was aimed at investigating the association of IL-1 and IL-6 gene polymorphisms with systemic BMD and CBL around dental implants. Methods: A total of 190 participants undergoing dental implantation in the mandibular posterior region were selected according to predetermined selection criteria and divided into a normal BMD group (NBD, 93 participants, T-score > -1) and low BMD group (LBD, including both osteoporosis and osteopenia, 97 participants, T-score < -1 standard deviation) according to the BMD of the right femoral neck, measured with dualenergy X-ray absorptiometry. Dental implants were placed through the standard surgical protocol, and CBL was calculated after 6 months with cone beam computed tomography scans before second-stage surgery. Genotyping was performed on all participants for IL-1A-889 A/G, IL-1B-511G/A, IL-1Bþ3954, and IL-6-572 C/G gene polymorphisms. Results: The demographic and clinical characteristics of the participants in both groups were compared with t-test and chi-square test (c2). The associations of NBD and LBD with the different genotypes and CBL was determined with odds ratios, and p < 0.05 was considered statistically significant. The frequency of IL-1B-511AA and IL-6-572 GG genotypes was significantly higher in LBD than in NBD (p < 0.05). In LBD, the IL-1B-511 AA (AA vs GA þ GG; p = 0.001) and IL-6-572 GG (GG vs CC þ GC; p ¼ 0.001) genotypes were significantly associated with higher peri-implant CBL. Conclusions: Individuals with the IL-1B-511 AA or IL-6- 572 GG genotype had elevated risk of osteoporosis/ osteopenia and were more susceptible to CBL around dental implants.
URI: http://localhost:8080/xmlui/handle/123456789/7838
ISSN: 1658-3612
Appears in Collections:Vol 19 No 2 (2024)

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