Potential of Ethanolic Extract from Ripe Musa balbisiana Colla Fruit Using Ultrasound-Assisted Extraction as An Antioxidant and Anti-Gout

Abstract

Plant extracts or their secondary metabolites have functioned as antioxidants in phytotherapy drugs which function as protection against various diseases related to oxidative stress and free radicals. Free radicals play an important role in the initiation and development of various diseases, one of which is uric acid. Hhis study aims to obtain ethanolic extract from the ripe fruit of Musa balbisiana Colla using the UAE method and obtain information about secondary metabolites and their bioactivity as antioxidants and anti-gout. The results showed that antioxidant activity test using the DPPH and FRAP methods gave IC50 values of 150.24 ± 0.0348 mg/L and 227.80 ± 0.0986 mg / L, respectively. The total phenolic content value of 625.64 ± 0.36 mg GAE/g ethanolic extract is thought to have a role in high antioxidant activity. In addition, ethanol extract with a concentration of 50 mg / L has activity in reducing uric acid levels by around 9%. It can be concluded that the ethanolic extract produced by UAE has potential as a source of anti-oxidants and anti-gout. Key words: Anti-gout, Antioxidant, Musa balbisiana Colla, Phenolic content, UAE.