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dc.contributor.authordel Carmen Juárez-Vázquez, María-
dc.date.accessioned2024-11-11T07:20:34Z-
dc.date.available2024-11-11T07:20:34Z-
dc.date.issued2021-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/7806-
dc.description.abstractCleoserrata serrata is used in Mexican-south traditional medicine to treat chicleros ulcer. The phytochemical profile and the anti-inflammatory effect from four extracts obtained by maceration proccess and of the primary fractions from two extracts are described. In addition, the antioxidant, leishmanicidal and antimycobaterial activities and LD50 from active extracts are reported. Anti-inflammatory activity was evaluated in TPA and carrageenan assays. Ethyl palmitate and γ-sitosterol were detected in Hexanic and CH2Cl2 extracts. Same compounds and stigmasta-3,5-dien-7-one, palmitic acid, phytol acetate and phytol were detected in primary fractions from CH2Cl2:EtOH extract. In this and in MeOH extracts a polyphenolmixture was obtained. The MeOH extract was subjected to acid hydrolysis, and kaempferol, quercetin and scopoletin were detected in organic-phase. Polyphenol-mixture and organic-phase (IC50=3730 and 2338 μg/mL) showed moderate antioxidant activity; meanwhile MeOH extract exhibited scarce activity. In carrageenan model, Hexanic extract and polyphenol-mixture showed ED50=131.46 and 64.89 mg/ kg, respectively. Three extracts were active but not-dose-dependent. In TPA-model, CH2Cl2 extract and polyphenol-mixture showed ED50 <0.79 mg/ear, and three extracts were active, however the effect was not-dose-dependent. CH2Cl2:EtOH showed antimycobacterial and leishmanicidal activities. The LD50 was >2 g/kg for all extracts. Key words: Cleoserrata serrata, Anti-inflammatory effect, Organic extract, DL50, Antioxidant activity, Leishmanicidal activity, Antimycobacterial activity.en_US
dc.subjectCleoserrata serrataen_US
dc.subjectAnti-inflammatory effecten_US
dc.subjectOrganic extracten_US
dc.subjectDL50en_US
dc.subjectAntioxidant activityen_US
dc.subjectLeishmanicidal activityen_US
dc.subjectAntimycobacterial activityen_US
dc.titlePhytochemical Screening and Anti-Inflammatory Potential of the Organic Extracts from Cleoserrata serrata (Jacq.) Iltisen_US
dc.typeArticleen_US
Appears in Collections:VOL 13 NO 5 2021

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