IL-10 (-1082 G/A) polymorphism in Bataknese with schizophrenia

Abstract

Objectives: Three biallelic polymorphisms at the promoter region of the interleukin-10 (IL-10) gene have been associated with susceptibility to schizophrenia. The aim of this case-control study was to investigate the association between IL-10 ( 1082) G/A gene polymorphisms and schizophrenia among Bataknese, a native tribe inhabiting the North Sumatera province in Indonesia. Methods: A total of 194 unrelated participants (n ¼ 97 for each case and control groups) participated in this study. Polymerase chain reaction restriction fragment length polymorphism molecular genotyping was conducted to assess the genotype and allele distribution of IL-10 ( 1082 G/A). Results: Allele variations indicated that the dominant allele in the Batak tribe was allele A, whereas homozygous GG genotypes were not found in either group. The A allele and AA genotype were found to be risk factors for developing schizophrenia (OR ¼ 2.26, 95% CI ¼ 1.1825e4.3559 and OR ¼ 2.56, 95% CI ¼ 1.280 e5.152, respectively). Conclusion: Only the A allele and AA genotype of the IL- 10 gene polymorphism at 1082 G/A contribute to schizophrenia susceptibility in Bataknese.