Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/7759
Title: Anti-inflammatory effects of banana (Musa balbisiana) peel extract on acne vulgaris: In vivo and in silico study
Authors: Savitri, Dwiana
Wahyuni, Sitti
Bukhari, Agussalim
Djawad, Khairuddin
Hatta, Mochammad
Riyanto, Puguh
Bahar, Burhanuddin
Wahab, Siswanto
Hamid, Firdaus
Rifai, Yusnita
Keywords: Anti-inflammation
Antibacterial
In silico
In vivo
Musa balbisiana
Issue Date: 2023
Publisher: Journal of Taibah University Medical Sciences
Series/Report no.: Original Article;1586-1598
Abstract: Objective: Acne vulgaris (AV) is a common problem with a relatively high incidence rate among Asian people. The potential antimicrobial and anti-inflammatory properties of banana peels have been demonstrated in previous studies but have not been studied in cases of AV. Therefore, this study was aimed at investigating the protective effects of banana (Musa balbisiana) peel extract (MBPE) against AV. Methods: Thirty rats were divided into five groups (n ¼ 6 rats per group): an AV group, AV group treated with 0.15% MBPE, AV group administered 0.30% MBPE, AV group administered 0.60% MBPE, and AV group administered clindamycin (the standard drug treatment). We assessed nodule size, bacterial count, histopathology, and cytokine levels (IL-1a, IFN-g, tumor necrosis factor (TNF)-a, and IL-8). Enzyme linked immunoassays were used to measure the cytokine levels. In addition, we performed molecular docking studies to determine the interactions between phytochemicals (trigonelline, vanillin, ferulic acid, isovanillic acid, rutin, and salsolinol) via the Toll-like receptor 2 (TLR2) and nuclear factorkappa B (NF-kB) pathways. Results: All MBPE treatment groups, compared with the AV group, showed suppression of both bacterial growth and proinflammatory cytokine production, as well as resolved tissue inflammation. The nodule size was significantly suppressed in the groups receiving the two highest doses of MBPE, compared with the AV group. However, the pharmacological action of MBPE remained inferior to that of clindamycin. Docking studies demonstrated that rutin was the phytocompound with the most negative interaction energy with TLR2 or NF-kB. Conclusions: Our results indicated that MBPE has antiinflammatory effects against AV, by suppressing nodule formation, inhibiting bacterial growth, and decreasing proinflammatory cytokine production.
URI: http://localhost:8080/xmlui/handle/123456789/7759
ISSN: 1658-3612
Appears in Collections:Vol 18 No 6 (2023)

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