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dc.contributor.authorJiménez, MA Alfaro-
dc.date.accessioned2024-11-11T02:54:08Z-
dc.date.available2024-11-11T02:54:08Z-
dc.date.issued2021-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/7718-
dc.description.abstractIntroduction: Parthenium hysterophorus is a plant used in traditional medicine to treat health issues and which could be a source of phytochemicals with possible antioxidant activity without causing cytotoxic effects. Hence, this work was designed to evaluate its phytochemical profile, cytotoxicity, and antioxidant activity. Methods: The aqueous (AE) and ethanolic (EE) extracts of P. hysterophorus flowers were obtained by decoction and ultrasound, respectively. Their phytochemical composition was determined by colorimetric tests and RP-HPLC-MS analysis. Their cytotoxic activity was tested by a hemolysis assay. The antioxidant activity was evaluated with the Trolox equivalent antioxidant capacity (TEAC), 2,2-diphenyl-1- picrylhydrazyl (DPPH), and hydroxyl radical (-OH) scavenging assays. In addition, the effect of the extracts on the activity of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) from human erythrocytes, was evaluated. Results: The phytochemical screening of the AE and EE by colorimetric test showed the presence of flavonoids, steroids, triterpenes, saponins, coumarins, sesquiterpene lactones, tannins, and carbohydrates. In addition, the RP-HPLC-MS analysis identified some phenolic compounds such as flavonols, methoxyflavonols, flavones, methoxyflavones, and hydroxycinnamic acids. The hemolysis assay showed non-cytotoxic activity by AE, but EE exhibited a hemolytic effect. Furthermore, the AE and EE showed significant antioxidant activity to inhibit radicals in the TEAC, DPPH and -OH scavenging assays. Moreover, the SOD activity only showed a significant increase by AE. However, the two crude extracts increased the CAT activity, at the highest concentrations. Conclusion: P. hysterophorus has phytochemicals with antioxidant activity to inhibit radicals and increase the activity of antioxidant enzymes in vitro. Key words: Parthenium hysterophorus, Phytochemicals, Cytotoxicity, Antioxidant activity.en_US
dc.subjectParthenium hysterophorusen_US
dc.subjectPhytochemicalsen_US
dc.subjectCytotoxicityen_US
dc.subjectAntioxidant activityen_US
dc.titlePhytochemical and Biological Characterization of Aqueous and Ethanolic Extracts of Parthenium hysterophorusen_US
dc.typeArticleen_US
Appears in Collections:VOL 13 NO 5 2021

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