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Title: | Myocardium Neutrophil Infiltration in Rat Model with Acute Myocardial Infarction Treated by Ramipril |
Authors: | Oktomalioputri, Biomechy Savitri, Meutia Dillasamola, Dwisari Noverial, Noverial |
Keywords: | Neutrophils Acute Myocardial Infarction (AMI) ACE Inhibitors Ramipril |
Issue Date: | 2021 |
Abstract: | Introduction: Acute myocardial infarction (AMI) is a cardiovascular disease that attacks myocardial cells due to long-standing ischemia. In AMI there is neutrophil infiltration associated with the prognosis of the disease. One of the initial therapies for AMI is ACE inhibitors. Objective: To determine myocardial neutrophil infiltration In rat model with acute myocardial infarction which is given ramipril as an Ace inhibitor. Method: This research is an experimental study using the Post Test Only Control Group study design. This study used 24 experimental rats which were divided into 3 treatment groups. Data were analyzed using the One Way ANOVA test and the Least Significant Differences test. Results: The results obtained were the mean number of neutrophils in the K(-) group was 1.83, the K(+) group was 22.67, and the successive treatment group was 4,17. Significant differences were obtained between the K(+) group and the treatment group where the p value was 0.001 (p <0.05). Conclusion: There is an effect of 4 mg/kg BW ACE Inhibitor ramipril and on the number of myocardial neutrophils of rats with AMI. Keywords: Neutrophils, Acute Myocardial Infarction (AMI), ACE Inhibitors, Ramipril |
URI: | http://localhost:8080/xmlui/handle/123456789/7717 |
Appears in Collections: | VOL 13 NO 5 2021 |
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