Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/7711
Title: Bone repair and key signalling pathways for cell-based bone regenerative therapy: A review
Authors: Nasir, Nur Julia N.
Arifin, Norsyahida
Noordin, Khairul Bariah A.A.
Yusop, Norhayati
Keywords: Bone
Cell-based therapy
Regeneration
Signalling pathway
Stem cells
Issue Date: 2023
Publisher: Journal of Taibah University Medical Sciences
Series/Report no.: Review Article;1350-1363
Abstract: Advances in cell-based regenerative therapy create new opportunities for the treatment of bone-related disorders and injuries, by improving the reparative phase of bone healing. Apart from the classical approach of bone grafting, the application of cell-based therapies, particularly stem cells (SCs), has gained a lot of attention in recent years. SCs play an important role in regenerative therapy due to their excellent ability to differentiate into bone-forming cells. Regeneration of new bone is regulated by a wide variety of signalling molecules and intracellular networks, which are responsible for coordinating cellular processes. The activated signalling cascade is significantly involved in cell survival, proliferation, apoptosis, and interaction with the microenvironment and other types of cells within the healing site. Despite the increasing evidence from studies conducted on signalling pathways associated with bone formation, the exact mechanism involved in controlling the differentiation stage of transplanted cells is not well understood. Identifying the key activated pathways involved in bone regeneration may allow for precise manipulation of the relevant signalling molecules within the progenitor cell population to accelerate the healing process. The in-depth knowledge of molecular mechanisms would be advantageous in improving the efficiency of personalised medicine and targeted therapy in regenerative medicine. In this review, we briefly introduce the theory of bone repair mechanism and bone tissue engineering followed by an overview of relevant signalling pathways that have been identified to play an important role in cell-based bone regenerative therapy.
URI: http://localhost:8080/xmlui/handle/123456789/7711
ISSN: 1658-3612
Appears in Collections:Vol 18 No 6 (2023)

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