Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/7637
Title: Virgin coconut oil reverses behavioral phenotypes of letrozole-model of PCOS in Wistar rats via modulation of NRF2 upregulation
Authors: Akintoye, Olabode O.
Ajibare, Ayodeji J.
Omotuyi, Idowu O.
Keywords: Acetylcholine esterase
Anxiety
Memory
Oxidative stress
Polycystic ovarian syndrome
Virgin coconut oil
Issue Date: 2023
Publisher: Journal of Taibah University Medical Sciences
Series/Report no.: Original Article;831-841
Abstract: Objectives: Polycystic ovarian syndrome (PCOS) is an endocrine disorder associated with insulin resistance, hyperandrogenism, and sub-infertility. Virgin coconut oil (VCO) has been reported to have health benefits, such as anti-inflammatory, anti-oxidant, and antiviral properties. This study investigated the effects of dietary VCO supplementation on memory and cognitive impairment in female rats with letrozole induced PCOS. Methods: Thirty female ratswere randomly divided into five groups.All rats except controls were treatedwith letrozole for 21 days to induce PCOSand were subsequently treated for 14 days with 10% VCO, clomiphene (CLO), or VCO þ CLO. Three neurobehavioral tests were conducted: elevated plus maze, Y maze, and novel object recognition tests. Results: Our results indicated statistically elevated serum concentrations of sex hormones in rats with PCOS, compared with the control and treated groups. In addition, all treated groups showed significant reversal of the low serum concentrations of catalase and down-regulated gene expression of Nrf2 in the hippocampus seen in the PCOS rats. In addition, gene expression of acetylcholine esterase was up-regulated in PCOS rats, and was statistically reverted in the VCO treated groups. Conclusion: Anxiety-like behavior and impaired shortterm memory were observed in PCOS rats; however, VCO supplementation reversed these effects by modulating the gene expression of Nrf2 and AchE.
URI: http://localhost:8080/xmlui/handle/123456789/7637
ISSN: 1658-3612
Appears in Collections:Vol 18 No 4 (2023)

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