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dc.contributor.authorAmiruddin, Amiruddin-
dc.contributor.authorAgus Syamsur Rijal, Muh.-
dc.contributor.authorMelani Hariyadi, , Dewi-
dc.date.accessioned2024-11-08T07:57:38Z-
dc.date.available2024-11-08T07:57:38Z-
dc.date.issued2023-12-06-
dc.identifier.issn25808303-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/7573-
dc.description.abstractAbstract Background: Ciprofloxacin HCl is a broad-spectrum fluoroquinolone antibiotic that has the lowest MIC against Mycobacterium tuberculosis but has limitations in oral use, so inhalation microspheres are made. Objective: This study aimed to investigate the effect of CaCl2 crosslinker concentration on the characteristics, release and stability of ciprofloxacin-alginate-carrageenan microspheres. Methods: Microspheres were prepared by ionotropic gelation using aerosolization with calcium chloride 0.5M (F1), 1.0M (F2), 1.5M (F3), 2.0M (F4) as crosslinker and then dried using freeze dryer. Results: Ciprofloxacin-alginate-carrageenan microspheres formed of yellowishwhite powder, smooth morphology and excellent flow properties with the particle size of less than 5µm, drug loading and entrapment efficiency were between 2.05% - 2.42% and 75.34% - 98.09%, yield was between 84.69% - 97.57%, moisture content of less than 10%. Ciprofloxacin-alginate-carrageenan microspheres with 1.5M crosslinker (F3) was the optimal formula. For 12 hours, ciprofloxacin released was 49.89% - 63.78% at pH 7.4, and the kinetics of drug release showed that of Korsmeyer-peppas with a mechanism based on fickian diffusion. The microspheres were discovered to be stable for up to 28 days of storage. Conclusion: The increased concentration of the CaCl2 crosslinker from 0.5M to 2.0M decreased the particle size and drug release but increased the yield, drug loading and entrapment efficiency. Keywords: calcium chloride, characteristics, ciprofloxacin microspheres, release, stabilityen_US
dc.publisherFaculty of Pharmacy Univesrsitas Airlanggaen_US
dc.subjectcalcium chlorideen_US
dc.subject, characteristics,en_US
dc.subjectciprofloxacin microspheres,en_US
dc.subjectrelease,en_US
dc.subjectstabilityen_US
dc.titleEffect of CaCl2 Crosslinker Concentration On The Characteristics, Release and Stability of Ciprofloxacin HCl-Alginate-Carrageenan Microspheresen_US
dc.typeArticleen_US
Appears in Collections:VOL 10 NO 3 2023

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