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Title: | The Effect of Decyl Glucoside on Stability and Irritability of Nanostructured Lipid Carriers-Green Tea Extract as Topical Preparations |
Authors: | Azzahrah, Rufaidah Rosita, Noorma Agus Purwanto, Djoko Soeratri, Widji |
Keywords: | nanostructured lipid carriers, green tea extract, decyl glucoside, thermal cycling, Hen’s Egg Test on the chorioallantoic membrane |
Issue Date: | 9-Dec-2022 |
Publisher: | Faculty of Pharmacy Univesrsitas Airlangga |
Abstract: | Abstract Background: Green Tea Extract (GTE) is a natural antioxidant compound that can protect the skin from photocarcinogenesis (DNA damage due to ultraviolet exposure). GTE has low stability, which needs a delivery system such as Nanostructured Lipid Carriers (NLC) with decyl glucoside (DG) as a natural surfactant that at the right concentration can produce a significantly small particle size which can improve the stability of the NLC. Objective: To determine the effect of DG usage on the characteristics, physical stability, and irritability of NLCGTE preparation. Methods: NLC-GTE preparation used the High Shear Homogenization (HSH) method with three formulas, which contained DG 2%, 2.5%, and 3% consecutively. Afterwards, the characteristic and physical stability tests were conducted using the thermal cycling method for three cycles with two different temperatures (48 hours/cycle, 2 - 8°C and 40°C). The irritability test used Hen's Egg Test on the Chorioallantoic Membrane (HET-CAM) method. Results: Characteristic test of organoleptic showed that all formulas were white, odorless, and had a semi-solid consistency. However, the pH, particle size, and polydispersity index values from all formulas were within the normal range of values. The physical stability test result showed that 3% DG was the most stable formula. This formula was within the non-irritating range of values in HET-CAM. Conclusion: NLC-GTE with an increased concentration of DG as a surfactant can improve the characteristics and physical stability of the preparation. F3 (3% DG) is the best formula compared to other formulas and indicates non-irritating in the HETCAM test. Keywords: nanostructured lipid carriers, green tea extract, decyl glucoside, thermal cycling, Hen’s Egg Test on the chorioallantoic membrane |
URI: | http://localhost:8080/xmlui/handle/123456789/7526 |
ISSN: | 25808303 |
Appears in Collections: | VOL 9 NO 3 2022 |
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