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dc.contributor.authorNur Muhammad Ansori, Arif-
dc.contributor.authorFadholly, Amaq-
dc.contributor.authorProboningrat, Annise-
dc.contributor.authorAntonius, Yulanda-
dc.contributor.authorHayaza, Suhailah-
dc.contributor.authorJoko Kuncoroningrat Susilo, Raden-
dc.contributor.authorInayatillah, Bilqis-
dc.contributor.authorTriandala Sibero, Mada-
dc.contributor.authorWar Naw, Sin-
dc.contributor.authorAnn Villar Posa, Gabrielle-
dc.contributor.authorHari Sucipto, Teguh-
dc.contributor.authorSoegijanto, Soegeng-
dc.date.accessioned2024-11-07T04:37:23Z-
dc.date.available2024-11-07T04:37:23Z-
dc.date.issued2021-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/7484-
dc.description.abstractIntroduction: Dengue virus (DENV) infection is general mosquito-transmitted viral taint. It can lead to the dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Dengue is a solemn illness with no endowed antiviral medication or recognized vaccine. Therefore, we aimed to investigate the activity of Annona squamosa leaf extract (ASLE) against dengue virus type-2 (DENV-2) isolated from Surabaya, Indonesia in 2013 (NCBI accession number: KT012509). Methods: In this study, the antiviral activity of ASLE was evaluated against DENV- 2 in Vero cells using Viral ToxGlo™ Assay. In addition, we used CellTiter-Glo® Luminescent Cell Viability Assay to set the amount of viable cells in culture based on quantitation of the ATP. Results: DENV-2 replication inhibited by ASLE in Vero cells with IC50 = 73.78 μg/mL and SI = 4.49 when cells were treated two days after virus infection, whereas its CC50 for cytotoxicity to Vero cells was 331.54 μg/mL. Interestingly, this is the first report on the investigation of ASLE against DENV-2. Conclusion: In summary, ASLE demonstrated the antiviral activity against DENV-2 with less toxicity, and high possibility as a drug candidate. Therefore, it might be suggested for in vivo assessment in the progress of a potent antiviral against DENV-2. Key words: Annona squamosa, Antiviral activity, DENV-2, Vero cellsen_US
dc.subjectAnnona squamosaen_US
dc.subjectAntiviral activityen_US
dc.subjectDENV-2en_US
dc.subjectVero cellsen_US
dc.titleNovel Antiviral Investigation of Annona squamosa Leaf Extract against the Dengue Virus Type-2: In Vitro Studyen_US
dc.typeArticleen_US
Appears in Collections:VOL 13 NO 2 2021

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