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DC Field | Value | Language |
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dc.contributor.author | Nur Muhammad Ansori, Arif | - |
dc.contributor.author | Fadholly, Amaq | - |
dc.contributor.author | Proboningrat, Annise | - |
dc.contributor.author | Antonius, Yulanda | - |
dc.contributor.author | Hayaza, Suhailah | - |
dc.contributor.author | Joko Kuncoroningrat Susilo, Raden | - |
dc.contributor.author | Inayatillah, Bilqis | - |
dc.contributor.author | Triandala Sibero, Mada | - |
dc.contributor.author | War Naw, Sin | - |
dc.contributor.author | Ann Villar Posa, Gabrielle | - |
dc.contributor.author | Hari Sucipto, Teguh | - |
dc.contributor.author | Soegijanto, Soegeng | - |
dc.date.accessioned | 2024-11-07T04:37:23Z | - |
dc.date.available | 2024-11-07T04:37:23Z | - |
dc.date.issued | 2021 | - |
dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/7484 | - |
dc.description.abstract | Introduction: Dengue virus (DENV) infection is general mosquito-transmitted viral taint. It can lead to the dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Dengue is a solemn illness with no endowed antiviral medication or recognized vaccine. Therefore, we aimed to investigate the activity of Annona squamosa leaf extract (ASLE) against dengue virus type-2 (DENV-2) isolated from Surabaya, Indonesia in 2013 (NCBI accession number: KT012509). Methods: In this study, the antiviral activity of ASLE was evaluated against DENV- 2 in Vero cells using Viral ToxGlo™ Assay. In addition, we used CellTiter-Glo® Luminescent Cell Viability Assay to set the amount of viable cells in culture based on quantitation of the ATP. Results: DENV-2 replication inhibited by ASLE in Vero cells with IC50 = 73.78 μg/mL and SI = 4.49 when cells were treated two days after virus infection, whereas its CC50 for cytotoxicity to Vero cells was 331.54 μg/mL. Interestingly, this is the first report on the investigation of ASLE against DENV-2. Conclusion: In summary, ASLE demonstrated the antiviral activity against DENV-2 with less toxicity, and high possibility as a drug candidate. Therefore, it might be suggested for in vivo assessment in the progress of a potent antiviral against DENV-2. Key words: Annona squamosa, Antiviral activity, DENV-2, Vero cells | en_US |
dc.subject | Annona squamosa | en_US |
dc.subject | Antiviral activity | en_US |
dc.subject | DENV-2 | en_US |
dc.subject | Vero cells | en_US |
dc.title | Novel Antiviral Investigation of Annona squamosa Leaf Extract against the Dengue Virus Type-2: In Vitro Study | en_US |
dc.type | Article | en_US |
Appears in Collections: | VOL 13 NO 2 2021 |
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