Please use this identifier to cite or link to this item:
http://localhost:8080/xmlui/handle/123456789/7461
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sumarawati, Titiek | - |
dc.contributor.author | Chodidjah | - |
dc.contributor.author | Nasihun, Taufiqurrachman | - |
dc.date.accessioned | 2024-11-07T03:35:56Z | - |
dc.date.available | 2024-11-07T03:35:56Z | - |
dc.date.issued | 2021-05 | - |
dc.identifier.citation | Research Article | en_US |
dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/7461 | - |
dc.description.abstract | Introduction: Curcuma zedoaria (CZ) has been proven capable of inducing apoptosis in cells cancer. CZ extraction can be performed by ethanol and acetyl acetate as solvent. However, which one of these extracts is superior remains unclear. Objective: This study aimed to investigate the difference potential effect of ethanol and acetyl CZ extract on apoptosis of T47D cell line. Methods: In this study 21 wells were assign into seven groups: control group (T47D); treatment groups consisting of group of ethanol CZ extract 46 (EtZ-46); group of ethanol CZ extract 23 (EtZ-23); group of ethanol CZ extract 11 (EtZ-11); and group of ethyl acetate CZ extract 111 (AcZ-111); group of ethyl acetate CZ extract 55 (AcZ-55); and group of ethyl acetate CZ extract 27 (AcZ-27). In T47D group only loaded with T47D cell line; in treatment groups aside from loaded with T47D cell line culture, also treated with ethanol or acetyl acetate CZ extract respectively. Concentration of T47D cell was 5 x 104 T47D cells line in 100 µl suspension loaded on each well of 21 wells and kept in CO2 incubator overnight. The apoptosis cells were measured after 48 hours post CZ treatment. Results: Post Hoc analysis indicated that the number of apoptosis cells in AcZ-111 was significant higher compared to that of other groups, p<0.05. Conclusion: Acetyl acetate CZ extract treatment with dose 111 µg was capable of inducing apoptosis in T47D cell line superior than that of other groups including ethanol CZ extract | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Pharmacogn J. | en_US |
dc.subject | Curcuma zedoaria | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Necrosis | en_US |
dc.subject | T47D cell line | en_US |
dc.subject | Ethanol | en_US |
dc.subject | Acetyl acetate | en_US |
dc.title | Both Ethanol and Ethyl Acetate Curcuma Zedoaraia Extract was Capable of Inducing Cells Death in T47D Cell Line Culture | en_US |
dc.type | Article | en_US |
Appears in Collections: | VOL 13 NO 3 2021 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.