Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/7375
Title: Amlodipine-Candesartan Combination: A Cost-Effective Strategy for Successful Therapy of Hypertension
Authors: Fitria, Najmiatul
Syaputri, Yolanda Zazna
Akram, Muhammad
Nasif, Hansen
Mardatillah
Keywords: amlodipine
antihypertension
candesartan
cost-effectiveness analysis
incremental cost-effectiveness ratio
Issue Date: Apr-2024
Publisher: Jurnal Sains Farmasi & Klinis
Citation: Original Article
Abstract: Introduction: The combination of amlodipine and candesartan can have a better effect, although the costeffectiveness analysis was not yet determined. This research aimed to establish the Incremental Cost-Effectiveness Ratio (ICER) value among outpatients with hypertension who used amlodipine-candesartan. Method: This research was a descriptive study that retrospectively gathered data from medical records . Medical records data focused on information for hypertensive patients at Universitas Andalas Hospital in 2021. This study compared the standard treatment involving amlodipine-candesartan and sole amlodipine, next to calculate the ICER using cost-effectiveness analysis. Results: Out of the total population of 284, as many as 73 patients were involved in this study. Among these, 21 patients (28.77%) were treated with amlodipine alone, while 52 (71.23%) received an amlodipine-candesartan combination. The Incremental Cost-Effectiveness Ratio (ICER) for reducing systolic blood pressure was IDR 74,738.10 per one mmHg decrease in the northeast quadrant of the cost-effectiveness chart. The ICER for lowering diastolic blood pressure was IDR 205,918.24 per one mmHg decrease in the northeast quadrant on the cost-effectiveness chart. Conclusion: The cost of the amlodipine-candesartan combination yields superior effects; however, warranting a probabilistic sensitivity analysis to determine its ICER robustness is essential for its effective implementation.
URI: http://localhost:8080/xmlui/handle/123456789/7375
Appears in Collections:VOL 11 NO 1 2024

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