Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/7359
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dc.contributor.authorFitriani, Lili-
dc.contributor.authorSimbolon, Clara Alverina-
dc.contributor.authorZaini, Erizal-
dc.date.accessioned2024-11-06T07:51:56Z-
dc.date.available2024-11-06T07:51:56Z-
dc.date.issued2023-12-
dc.identifier.citationOriginal Articleen_US
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/7359-
dc.description.abstractPiperine (C17 H19 NO3 ) belongs to the alkaloid group mainly found in the Piperaceae family, especially in black pepper (Piper nigrum L.). Piperine is practically insoluble in water. This study aims to improve the solubility of piperine by preparing it into a multicomponent crystal using caffeine as a coformer. The formation of piperine-caffeine multicomponent was prepared by solvent evaporation and solvent drop grinding. Each sample was characterized using Powder X-ray diffraction (XRD), Differential Scanning Calorimetry (DSC), and FT-IR spectroscopy. The solubility test was carried out by sonication for 30 minutes at room temperature (30 ⁰C), and the dissolved piperine was analyzed by High-Performance Liquid Chromatography (HPLC) using methanol: water (80:20) as the mobile phase. This study shows a decrease in peak diffraction intensity on PXRD analysis and a reduction in endothermic peak on the DSC thermogram of multicomponent crystals. In the FTIR analysis, multicomponent crystals slightly shift, indicating the physical interaction. The multicomponent crystal of piperine-caffeine prepared by solvent evaporation method has an increase in solubility of 2.56 times, and the multicomponent crystal with solvent drop grinding method has an increase in solubility of 1.61 times, respectively. In conclusion, the multicomponent crystal piperine–caffeine can enhance the solubility of piperine.en_US
dc.language.isoen_USen_US
dc.publisherJurnal Sains Farmasi & Klinisen_US
dc.subjectpiperineen_US
dc.subjectcaffeineen_US
dc.subjectmulticomponent crystalen_US
dc.subjectsolvent evaporationen_US
dc.subjectsolvent drop grindingen_US
dc.titlePreparation and Characterization of Multicomponent Crystal Piperine-Caffeineen_US
dc.typeArticleen_US
Appears in Collections:VOL 10 NO 3 2023

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