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Title: | Effect of Quercetin and Avobenzone Concentration on Physical Characteristics and In Vitro Activity of Sunscreen |
Authors: | Wisudyaningsih, Budipratiwi Barikah, Kuni Zu’aimah Lita, Fernanda Indah |
Keywords: | sunscreen quercetin avobenzone factorial design |
Issue Date: | Dec-2023 |
Publisher: | Jurnal Sains Farmasi & Klinis |
Citation: | Original Article |
Abstract: | Quercetin is a flavonoid compound that has great potential activity, one of which is a chemical absorber of ultraviolet (UV) radiation, especially UV B radiation. The objective of the present study was to optimize quercetin as a UV B absorber combined with avobenzone as a UV A absorber in sunscreen cream formulation. Optimization was carried out by factorial design method using Design Expert 11.0 Software, with viscosity, pH, Sun Protection Factor (SPF) value, Percent of Erythema Transmission (% TE), and Percent of Pigmentation Transmission (% TP). The results showed that the quercetin factor was decreasing viscosity, pH, % TE, and % TP value but increasing the SPF value of the formulation. Avobenzone factor affected the increase of viscosity, pH, and SPF value but decreased the % TE and TP value. The interaction of quercetin and avobenzone significantly affected decreasing the viscosity and pH value but increased the SPF < % TE, and % TP value. Evaluation of optimum formula obtained by the overlay contour plot on the software resulting viscosity cream at 338,33 dPas, pH value at 5,40; SPF value at 33,31; % TE at 2,62x10 -3 % and % TP at 1,56x10 -5 %. |
URI: | http://localhost:8080/xmlui/handle/123456789/7352 |
Appears in Collections: | VOL 10 NO 3 2023 |
Files in This Item:
File | Description | Size | Format | |
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333-339.pdf | 587.9 kB | Adobe PDF | View/Open |
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