Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/7324
Title: In Vitro Antimalarial Activity and Toxicity of Helianthus annuus L. Leaf Extract against Plasmodium falciparum
Authors: Marangoh, Nuriha
Suciati, Suciati
Ekasari, Wiwied
Keywords: antimalarial,
Helianthus annuus L.,
Plasmodium falciparum,
IC50,
cytotoxicity
Issue Date: 30-Nov-2021
Publisher: Faculty of Pharmacy Univesrsitas Airlangga
Abstract: Abstract Background: Malaria is one of the public health problems in Indonesia. The morbidity rate is still quite high, especially in the eastern part of Indonesia. Objective: This study aimed to determine the inhibitory activity of the leaf extracts of Helianthus annuus L. against Plasmodium falciparum strain 3D7 as well as the cytotoxicity of the extracts. Methods: The leaves of H. annuus were extracted by the maceration method with n-hexane, chloroform, and ethanol 96% to increase polarity. The antimalarial assay was performed by using Trager and Jensen method, and the cytotoxicity test was carried out by the MTT method. Results: The results of antimalarial study showed that the chloroform extract had IC50 value of 0.002 µg/mL and CC50value of 138.03 µg/mL, 96% ethanol extract had an IC50 value of 0.02 µg/mL and CC50 value of 617.81 µg/mL, and n-hexane extract had an IC50 value of 1.29 µg/mL and CC50 value of 104.89 µg/mL. The selectivity index (SI) values of the chloroform, ethanolic, and nhexane extracts were calculated and obtained 69,015.00, 30,890.50, and 81.31, respectively. Conclusion: To conclude, the chloroform extract of H. annuusL. leaf gave strong antimalarial activity against P. falciparum strain 3D7 without any cytotoxicity; therefore, H. annuus L. leaf can be a good candidate for the development of an antimalarial drug. Keywords: antimalarial, Helianthus annuus L., Plasmodium falciparum, IC50, cytotoxicity
URI: http://localhost:8080/xmlui/handle/123456789/7324
ISSN: 25808303
Appears in Collections:VOL 8 NO 3 2021

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